{"id":50104,"date":"2021-06-06T20:42:42","date_gmt":"2021-06-06T20:42:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-comparativo-del-efecto-de-clotiapina-y-doxepina-sobre-la-actividad-oxidativa-del-cerebro-de-rata-in-vitro\/"},"modified":"2021-06-06T20:42:42","modified_gmt":"2021-06-06T20:42:42","slug":"estudio-comparativo-del-efecto-de-clotiapina-y-doxepina-sobre-la-actividad-oxidativa-del-cerebro-de-rata-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-comparativo-del-efecto-de-clotiapina-y-doxepina-sobre-la-actividad-oxidativa-del-cerebro-de-rata-in-vitro\/","title":{"rendered":"Estudio comparativo del efecto de clotiapina y doxepina sobre la actividad oxidativa del cerebro de rata in vitro"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Garcia Roldan <\/strong><\/h2>\n<p>En este trabajo se estudian los efectos de clotiapina y doxepina sobre el metabolismo oxidativo de cerebro de rata  in vitro . El consumo de oxigeno se determina por tecnica manometrica  el consumo de glucosa por el metodo de la glucosa-oxidasa  el de fosforo fotocolorimetricamente  tambien se determina la actividad atpasa (na-k) dependiente. La clotiapina inhibe la actividad atpasa (na-k) dependiente y el consumo de oxigeno con ella relacionado  asi como el incremento de consumo de oxigeno inducido por dopamina en cortes de cerebro de rata  in vitro . La doxepina desacopla la fosforilizacion oxidativa mitocondrial  no modifica la actividad atpasa (na-k) dependiente  no antagoniza el incremento de consumo de oxigeno inducido por dopamina pero si el incremento inducido por histamina. Se discuten los resultados basandose en el isosterismo existente entre ambos farmacos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo del efecto de clotiapina y doxepina sobre la actividad oxidativa del cerebro de rata in vitro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo del efecto de clotiapina y doxepina sobre la actividad oxidativa del cerebro de rata in vitro <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Garcia Roldan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1982<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Velasco Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Valentin Conde  Lopez <\/li>\n<li>Alfonso Velasco Martin (vocal)<\/li>\n<li>\u00e1ngel Mara\u00f1\u00f3n Cabello (vocal)<\/li>\n<li>Enrique Barbosa Ayucar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Garcia Roldan En este trabajo se estudian los efectos de clotiapina y doxepina sobre el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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