{"id":51723,"date":"2021-11-04T10:11:35","date_gmt":"2021-11-04T10:11:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-un-modelo-experimental-de-cultivo-primario-de-hepatocitos-de-rata-adulta-en-ausencia-de-suero-bovino-fetal\/"},"modified":"2021-11-04T10:11:35","modified_gmt":"2021-11-04T10:11:35","slug":"desarrollo-de-un-modelo-experimental-de-cultivo-primario-de-hepatocitos-de-rata-adulta-en-ausencia-de-suero-bovino-fetal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/desarrollo-de-un-modelo-experimental-de-cultivo-primario-de-hepatocitos-de-rata-adulta-en-ausencia-de-suero-bovino-fetal\/","title":{"rendered":"Desarrollo de un modelo experimental de cultivo primario de hepatocitos de rata adulta en ausencia de suero bovino fetal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jos\u00e9 G\u00f3mez-lech\u00f3n Moliner <\/strong><\/h2>\n<p>La presencia de suero bovino fetal (sbf) constituye una limitacion experimental en los cultivos de hepatocitos convencionales. Sin embargo  el sbf cumple una funcion mediante la adhesion y ectension celular sobre el soporte para cultivo y aportando nutrientes. Se ha estudiado este papel de sbf en cada una de las diferentes etapas del cultivo y en que medida es substituible por factores especificos sericos o no sericos en cada una de ellas. El modelo experimental de cultivo de hepatocitos de rata adulta se basa en: 1) el aislamiento de los hepatocitos por perfusion del higado  mediante un tratamiento que ocasione el minimo da\u00f1o celular. 2) la utilizacion de fibronectina de sueros de diferentes especies animales como soporte para cultivo y 3) el dise\u00f1o de un medio de cultivo que lo favorezca en cada una de sus etapas. En este sentido es necesario el medio ham f-12 quimicamente definido  complementado con dexametasona e insulina para mantener la funcionalidad adulta a lo largo de los dias de cultivo y con glucaggon y albumina para asegurar la completa extension celular sobre el soporte.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de un modelo experimental de cultivo primario de hepatocitos de rata adulta en ausencia de suero bovino fetal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de un modelo experimental de cultivo primario de hepatocitos de rata adulta en ausencia de suero bovino fetal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jos\u00e9 G\u00f3mez-lech\u00f3n Moliner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1983<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Baguena Candela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez Garcia <\/li>\n<li>Rafael Sentandreu Ramon (vocal)<\/li>\n<li>Federico Uruburu Fern\u00e1ndez (vocal)<\/li>\n<li>Luis Franco Vera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jos\u00e9 G\u00f3mez-lech\u00f3n Moliner La presencia de suero bovino fetal (sbf) constituye una limitacion experimental en los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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