{"id":51808,"date":"2021-11-18T13:48:27","date_gmt":"2021-11-18T13:48:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-a-la-farmacologia-del-trazodone\/"},"modified":"2021-11-18T13:48:27","modified_gmt":"2021-11-18T13:48:27","slug":"aportacion-a-la-farmacologia-del-trazodone","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aportacion-a-la-farmacologia-del-trazodone\/","title":{"rendered":"Aportacion a la farmacolog\u00eda del trazodone"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Gonzalez Calvo Baeza <\/strong><\/h2>\n<p>El clorhidrato de trazodone es un farmaco antidepresivo atipico recientemente introducido en terapeutica. En este trabajo se estudia su efecto sobre el metabolismo oxidativo cerebral  asi como sus interaciones con neurotransmisores tales como acetilcolina  serotonina e histimina en preparaciones de organo aislado de cobayo y rata. El consumo de oxigeno se determina mediante tecnica manometrica  la actividad atp-asa mediante tecnica fotocolorimetrica y las interacciones con neurotransmisores mediante tecnicas de organo aislado. El trazodone a 10-3m disminuye el consumo de oxigeno de cortes y homogeneizados de cerebro de rata  desacopla la fosforilizacion oxidativa mitocondrail e inhibe la atp-asa de membrana sodio-potasio dependiente. A 10-7m antagoniza el incremento de consumo de oxigeno inducido por dopamina en cortes de cerebro de rata in vitro.  trazodone es debilmente anticolinergico  antihistaminico y antisrotoninico siendo este antagonismo no competitivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportacion a la farmacolog\u00eda del trazodone<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportacion a la farmacolog\u00eda del trazodone <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Gonzalez Calvo Baeza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1983<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Velasco Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez Y Sanchez-villares Ernesto <\/li>\n<li>Alfonso Velasco Martin (vocal)<\/li>\n<li>\u00e1ngel Mara\u00f1\u00f3n Cabello (vocal)<\/li>\n<li>Francisco Javier Casta\u00f1eda Casado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Gonzalez Calvo Baeza El clorhidrato de trazodone es un farmaco antidepresivo atipico recientemente introducido en terapeutica. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,12451],"tags":[12654,27683,9211,112849,115584],"class_list":["post-51808","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-valladolid","tag-alfonso-velasco-martin","tag-angel-maranon-cabello","tag-francisco-javier-castaneda-casado","tag-sanchez-y-sanchez-villares-ernesto","tag-vicente-gonzalez-calvo-baeza"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/51808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=51808"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/51808\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=51808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=51808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=51808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}