{"id":5240,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/heterogeneidad-de-las-celulas-somatotropas-hipofisarias-durante-el-envejecimiento-de-la-rata-macho\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"heterogeneidad-de-las-celulas-somatotropas-hipofisarias-durante-el-envejecimiento-de-la-rata-macho","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/heterogeneidad-de-las-celulas-somatotropas-hipofisarias-durante-el-envejecimiento-de-la-rata-macho\/","title":{"rendered":"Heterogeneidad de las celulas somatotropas hipofisarias durante el envejecimiento de la rata macho"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Dobado Berrios Pablo Manuel <\/strong><\/h2>\n<p>La disminucion de la secrecion hipofisaria de la hormona del crecimiento (gh) con la edad es un fenomeno comun a todas las especies de mamiferos. Dicho declive condiciona muchos de los cambios asociados al proceso general de envejecimiento. En este trabajo se investigan las causas de la disminucion de la secrecion de gh con la edad, estudiando la evolucion de dos subpoblaciones distintas de celulas productoras de gh en la rata wistar macho:  celulas gh de baja densidad, de bajo contenido intracelular de gh y debil actividad secretora \u00abin vitro\u00bb, pero con un reticulo endoplasmico rugoso muy desarrollado y elevados niveles de arnm-gh; y celulas gh de alta densidad, de caracteristicas opuestas a las anteriores. Con la edad, una y otra subpoblacion experimentan las mismas tendencias: disminucion de la actividad secretora, del almacenamiento de gh, del desarrollo de la maquinaria biosintetica y de los niveles de arnm-gh. Estos resultados demuestran que la reducida secrecion de gh con la edad es consecuencia de una menor secrecion y contenido de hormona a nivel de celulas gh individuales, condicionada por una sintesis hormonal reducida y afectada a nivel de la expresion genica de gh.  finalmente, el estudio postula que las dos subpoblaciones corresponden realmente a dos fases distintas de un ciclo secretor que ocurre a lo largo del tiempo en cada celula gh individual.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Heterogeneidad de las celulas somatotropas hipofisarias durante el envejecimiento de la rata macho<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Heterogeneidad de las celulas somatotropas hipofisarias durante el envejecimiento de la rata macho <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Dobado Berrios Pablo Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Gracia Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pl\u00e1cido Navas Lloret <\/li>\n<li>Gregorio Garc\u00eda Herdugo (vocal)<\/li>\n<li> Castrillo Diez Jos\u00e9 Luis (vocal)<\/li>\n<li>Luis Jimenez Reina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dobado Berrios Pablo Manuel La disminucion de la secrecion hipofisaria de la hormona del crecimiento (gh) con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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