{"id":52470,"date":"2022-03-06T01:53:37","date_gmt":"2022-03-06T01:53:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-al-estudio-de-la-necrosis-hepatica-por-sobredosis-de-paracetamol\/"},"modified":"2022-03-06T01:53:37","modified_gmt":"2022-03-06T01:53:37","slug":"aportacion-al-estudio-de-la-necrosis-hepatica-por-sobredosis-de-paracetamol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aportacion-al-estudio-de-la-necrosis-hepatica-por-sobredosis-de-paracetamol\/","title":{"rendered":"Aportacion al estudio de la necrosis hepatica por sobredosis de paracetamol."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Caracuel Ruiz M. Dolores <\/strong><\/h2>\n<p>El hecho de que la ranitidina no sea capaz de prevenir la hepatopatia por sobredosis de paracetamol  como lo hace la cimetidina  induce a suponer que la actividad hepatoprotectora de la cimetidina radica en el anillo imidazolico presente en esta  pero no en la ranitidina.  con esta hipotesis de trabajo  se reproduce la necrosis hepatica en el raton con paracetamol (500 mg\/kg). Tras comprobar una reduccion importante en la incidencia de necrosis por paracetamol (45% frente a 78%) cuando se administraba cimetidina (4.6 x 10 elevado a -4 moles\/kg) se incluye un grupo de 30 ratones en identicas condiciones experimentales y a los cuales se les administra imidasol (dosis equimolecular) dando lugar a una ausencia total de necrosis hepatica ademas de una notable disminucion de la actividad encimetica (ast y alt) con respecto al grupo control. Con estos datos parece razonable pensar que la actividad hepatoprotectora de la cimetidina frente a sobredosis de paracetamol reside en el anillo imidazolico de la molecula.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportacion al estudio de la necrosis hepatica por sobredosis de paracetamol.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportacion al estudio de la necrosis hepatica por sobredosis de paracetamol. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Caracuel Ruiz M. Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1984<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Nogales Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Nogales Fern\u00e1ndez <\/li>\n<li>Antonio Campos Fernandez (vocal)<\/li>\n<li>Sergio Erill Saez (vocal)<\/li>\n<li>Alfonso Moreno Gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Caracuel Ruiz M. Dolores El hecho de que la ranitidina no sea capaz de prevenir la hepatopatia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,52,483,156],"tags":[3585,116166,116165,4420,3584],"class_list":["post-52470","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-histopatologia","category-mecanismos-de-accion-de-los-farmacos","category-patologia","tag-alfonso-moreno-gonzalez","tag-antonio-campos-fernandez","tag-caracuel-ruiz-m-dolores","tag-francisco-nogales-fernandez","tag-sergio-erill-saez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=52470"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52470\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=52470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=52470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=52470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}