{"id":52774,"date":"2018-03-09T22:40:26","date_gmt":"2018-03-09T22:40:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-melatonina-en-la-hipnosis-anestesica-en-humanos-con-midazolam-y-propofol\/"},"modified":"2018-03-09T22:40:26","modified_gmt":"2018-03-09T22:40:26","slug":"papel-de-la-melatonina-en-la-hipnosis-anestesica-en-humanos-con-midazolam-y-propofol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/papel-de-la-melatonina-en-la-hipnosis-anestesica-en-humanos-con-midazolam-y-propofol\/","title":{"rendered":"Papel de la melatonina en la hipnosis anest\u00e9sica en humanos con midazolam y propofol"},"content":{"rendered":"

Tesis doctoral de Manuel Ruiz Castro <\/strong><\/h2>\n

Los estudios realizados sobre los efectos narc\u00f3ticos y sedantes de la melatonina parecen demostrar cierta capacidad hipn\u00f3tica. Por tanto algunas sustancias hipn\u00f3ticas podr\u00edan estar relacionadas con un incremento en los niveles plasm\u00e1ticos de esta hormona. M\u00e9todo: se ha realizado un estudio para intentar observar la posible influencia de la administraci\u00f3n de propofol y midazolam sobre los niveles plasm\u00e1ticos de melatonina. Para ello, se sometieron 30 pacientes sanos a anestesia espinal para cirug\u00eda trumatol\u00f3gica de miembros inferiores. Los sujetos fueron asignados aleatoriamente a tres grupos: sedaci\u00f3n con midazolam (0,05-0,1 mg\/kg\/h), sedaci\u00f3n con propofol (3-4 mg\/kg\/h) y anestesia espinal sin sedaci\u00f3n . Los valores obtenidos en los diferentes grupos fueron comparados con un grupo de controles basales, no sometidos ni a cirug\u00eda ni a sedaci\u00f3n, y con una curva te\u00f3rica, elaborada con valores tanto basales como en rango hipn\u00f3tico recogidos de la literatura, para poder apreciar si lo niveles plasm\u00e1ticos de melatonina ovtenidos llegaban a alcanzar los niveles que se observan en el sue\u00f1o natural. Los niveles de melatonina fueron determindos mediante elisa a los 10 y 60 minutos despu\u00e9s de iniciarse la sedaci\u00f3n, y 90 minutos tras concluir la misma. Los valores basales se obtuvieron en todos los grupos. Resultados: se apreciaron diferencias significativas en cuanto a los valores basales (p>0.269). Las concentraciones de melatonina circulante no variaron 60 minutos tras ser iniciada la sedaci\u00f3n (p=0.049) o 90 minutos tras la misma (p>0.093)- si se observaron diferencias significativas 10 minutos tras realizarse sedaci\u00f3n entre el grupo que no fue sometido a sedaci\u00f3n, y el sometido a sedaci\u00f3n con propofol (p<0.001) y la curva te\u00f3rica (p<0.001), respectivamente. Conclusiones: debido a que propofol produce un pico plasm\u00e1tico de melatonina, nosotros sugerimos un posible efecto de este f\u00e1rmaco hipn\u00f3tico sobre la gl\u00e1ndula pineal. Con midazolam no apreciamos cambios sobre los niveles plasm\u00e1ticos de melatonina.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abPapel de la melatonina en la hipnosis anest\u00e9sica en humanos con midazolam y propofol<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la melatonina en la hipnosis anest\u00e9sica en humanos con midazolam y propofol <\/li>\n
  • Autor:<\/strong>\u00a0 Manuel Ruiz Castro <\/li>\n
  • Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 26\/05\/2006<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Jos\u00e9 Luis Bardasano Rubio<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Francisco Zaragoza garcia <\/li>\n
        • Fernando Gilsanz rodr\u00edguez (vocal)<\/li>\n
        • Antonio Planas roca (vocal)<\/li>\n
        • Manuel Barcina sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Manuel Ruiz Castro Los estudios realizados sobre los efectos narc\u00f3ticos y sedantes de la melatonina parecen demostrar […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,141],"tags":[69916,30129,4080,17459,116443,116442],"class_list":["post-52774","post","type-post","status-publish","format-standard","hentry","category-alcala","category-cirugia","tag-antonio-planas-roca","tag-fernando-gilsanz-rodriguez","tag-francisco-zaragoza-garcia","tag-jose-luis-bardasano-rubio","tag-manuel-barcina-sanchez","tag-manuel-ruiz-castro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=52774"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52774\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=52774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=52774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=52774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}