{"id":52775,"date":"2018-03-09T22:40:26","date_gmt":"2018-03-09T22:40:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-del-lipopolisacarido-de-escherichia-coli-sobre-la-absorcion-de-d-galactosa-a-traves-de-yeyuno-de-conejo\/"},"modified":"2018-03-09T22:40:26","modified_gmt":"2018-03-09T22:40:26","slug":"accion-del-lipopolisacarido-de-escherichia-coli-sobre-la-absorcion-de-d-galactosa-a-traves-de-yeyuno-de-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/accion-del-lipopolisacarido-de-escherichia-coli-sobre-la-absorcion-de-d-galactosa-a-traves-de-yeyuno-de-conejo\/","title":{"rendered":"Accion del lipopolisacarido de escherichia coli sobre la absorcion de d- galactosa a traves de yeyuno de conejo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Pilar Amador Rodriguez <\/strong><\/h2>\n<p>The action of scherichia coli lipopolysacchart.De in de absortion of d-galactose across rabbit jejune ma del pilar amador rodr\u00edguez, faculty of farmacy, university of navarra (spain) 2006.  The aim of this work was to study the lps and tnf-a effect on intestinal absorption of d-galactose in rabbit. Moreover, we proposed to invest\u00edgate the possible mechanisms implicated in this action and characterize the effect on sgtl d-galactose transporter.  We assayed two work protocols: the tissue exposed directly to lps (local effect) and intravenous administrat!On of lps or tnf-a (systemic effect). Rabbit jejunum was used as the experimental model because it is the part of the small intestine with the highest lev\u00e9is of absorption. When lps was added directly to tissue there was a partial reduction of d-galactose transport located on the mucosa! Si de. The endotoxin did not modify d-galactose diffusi\u00f3n across the intestinal epithelium. However, the na+-dependent transport system was affected by lps with a diminution of the transporter affinity. In addition, we found a reduction of the na+\/ k+-atpase activity. In the lps inhibitory effect on d-galactose intestinal transport, intracellular processes related to pkc, ca2+-calm\u00ed\u00b2dul in and mapks (p38 mapk, jnk, mekl\/2) could be implicated. On the other hand, intravenous lps administration inhibited d-galactose absorption by reducing the number of sgltl transporters, with the possible implication of pkc, pka, mapks (p38 mapk, jnk, mekl\/2) and proteasome. Simi 1 ariy, the secretagoge action of this endotoxin on the gut mediated by cytokines as tnf-a could have contributed to this effect. On the other hand, we found that lps increase signi fi canti y the mrna-sgltl lev\u00e9is which could be related to mrna stability. The intravenous administration of tnf-a also produced an inhibition on d-galactose mucosal intestinal transport. This action could be produced by a reduction in the number of sgltl transporters. The pka, pkc, mapks and proteasome ways could be implicated. Likewise, tnf-a increased significantly the mrna-sgltl level.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion del lipopolisacarido de escherichia coli sobre la absorcion de d- galactosa a traves de yeyuno de conejo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion del lipopolisacarido de escherichia coli sobre la absorcion de d- galactosa a traves de yeyuno de conejo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Pilar Amador Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jes\u00fas Rodriguez Yoldi<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mar\u00ed\u00a7al Pastor anglada <\/li>\n<li>Ana Barber c\u00e1rcamo (vocal)<\/li>\n<li>reyes Barbera saez (vocal)<\/li>\n<li>Ana isabel \u00e1lvarez de felipe (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Pilar Amador Rodriguez The action of scherichia coli lipopolysacchart.De in de absortion of d-galactose across rabbit [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[16529,35,17749,546,1176],"tags":[17999,36086,32271,116444,12645,45347],"class_list":["post-52775","post","type-post","status-publish","format-standard","hentry","category-azucar","category-ciencias-de-la-vida","category-navarra","category-nutricion-veterinaria","category-nutrientes","tag-ana-barber-carcamo","tag-ana-isabel-alvarez-de-felipe","tag-maria-jesus-rodriguez-yoldi","tag-maria-pilar-amador-rodriguez","tag-marial-pastor-anglada","tag-reyes-barbera-saez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=52775"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52775\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=52775"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=52775"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=52775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}