{"id":52786,"date":"2018-03-09T22:40:26","date_gmt":"2018-03-09T22:40:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-en-animales-transgenicos-del-papel-del-incremento-en-la-gliceroneogenesis-o-en-la-captacion-de-glucosa-por-el-tejido-adiposo\/"},"modified":"2018-03-09T22:40:26","modified_gmt":"2018-03-09T22:40:26","slug":"analisis-en-animales-transgenicos-del-papel-del-incremento-en-la-gliceroneogenesis-o-en-la-captacion-de-glucosa-por-el-tejido-adiposo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-en-animales-transgenicos-del-papel-del-incremento-en-la-gliceroneogenesis-o-en-la-captacion-de-glucosa-por-el-tejido-adiposo\/","title":{"rendered":"An\u00e1lisis en animales transg\u00e9nicos del papel del incremento en la gliceroneog\u00e9nesis o en la captaci\u00f3n de glucosa por el tejido adiposo"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mu\u00f1oz Forero Sergio Antonio <\/strong><\/h2>\n<p>La obesidad y la diabetes de tipo 2 se han convertido en las dos grandes epidemias de los pa\u00edses desarrollados y en v\u00edas de desarrollo (james, 2004;zimmet et al., 2001). El conocimiento de las causas y mecanismos que desencadenan el desarrollo de obesidad, resistencia a la insulina y diabetes de tipo 2 es de vital importancia para su posterior prevenci\u00f3n y tratamiento. Tanto la producci\u00f3n de glicerol-3-fosfato como la obtenci\u00f3n de \u00e1cidos grasos libres son fundamentales para la s\u00edntesis de triglic\u00e9ridos por el tejido adiposo. Por tanto, alteraciones metab\u00f3licas primarias en el tejido adiposo que incrementen la obtenci\u00f3n de glicerol-3-fosfato podr\u00edan aumentar su capacidad de almacenar l\u00edpidos, induciendo el desarrollo de obesidad, resistencia a la insulina y diabetes de tipo 2. En condiciones fisiol\u00f3gicas, se considera que el adipocito produce glicerol-3-fosfato a partir de la glucosa durante el periodo post-prandial, o a trav\u00e9s de la gliceroneog\u00e9nesis durante el ayuno.  as\u00ed, en la primera parte de este estudio, se analizaron los efectos de un incremento en la gliceroneog\u00e9nesis del tejido adiposo a trav\u00e9s de la sobreexpresi\u00f3n de la fosfoenolpiruvato carboxiquinasa (pepck) en ratones transg\u00e9nicos. La sobreexpresi\u00f3n de pepck llevaba a un incremento en la reesterificaci\u00f3n de \u00e1cidos grasos y un mayor dep\u00f3sito de l\u00edpidos en tejido adiposo. Sin embargo, aunque estos animales presentaron obesidad hipertr\u00f3fica, mostraban una sensibilidad a la insulina y tolerancia a la glucosa similar a los controles. Ello probablemente era debido a la ausencia de niveles elevados de ffas, leptina y tnf-  circulantes, junto con la ausencia de dep\u00f3sito de grasa en tejidos no adiposos y altos niveles de adiponectina s\u00e9rica. Con el fin de estudiar si un incremento en la reesterificaci\u00f3n de \u00e1cidos grasos era capaz de contrarrestar el incremento en los niveles s\u00e9ricos de ffas y la resistencia a la insulina inducida por una dieta alta en l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis en animales transg\u00e9nicos del papel del incremento en la gliceroneog\u00e9nesis o en la captaci\u00f3n de glucosa por el tejido adiposo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis en animales transg\u00e9nicos del papel del incremento en la gliceroneog\u00e9nesis o en la captaci\u00f3n de glucosa por el tejido adiposo <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mu\u00f1oz Forero Sergio Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fatima Bosch Tubert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel roman Benito de las heras <\/li>\n<li>Antonio Carrascosa lezcano (vocal)<\/li>\n<li>francesc Villarroya gombau (vocal)<\/li>\n<li>diego Haro bautista (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mu\u00f1oz Forero Sergio Antonio La obesidad y la diabetes de tipo 2 se han convertido en las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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