{"id":52810,"date":"2018-03-09T22:40:26","date_gmt":"2018-03-09T22:40:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ensamblaje-de-la-capsida-del-parvovirus-mvm-transporte-nuclear-de-intermedios-trimericos-y-su-regulacion-por-fosforilacion\/"},"modified":"2018-03-09T22:40:26","modified_gmt":"2018-03-09T22:40:26","slug":"ensamblaje-de-la-capsida-del-parvovirus-mvm-transporte-nuclear-de-intermedios-trimericos-y-su-regulacion-por-fosforilacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/ensamblaje-de-la-capsida-del-parvovirus-mvm-transporte-nuclear-de-intermedios-trimericos-y-su-regulacion-por-fosforilacion\/","title":{"rendered":"Ensamblaje de la c\u00e1psida del parvovirus mvm: transporte nuclear de intermedios trim\u00e9ricos y su regulaci\u00f3n por fosforilaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Riolobos Santamar\u00eda <\/strong><\/h2>\n<p>Se ha investigado la regulaci\u00f3n del transporte nuclear de las prote\u00ednas estructurales de la c\u00e1psida durante el ensamblaje del parvovirus diminuto del rat\u00f3n (mvm). Las proteinas que forman la c\u00e1psida icosa\u00e9drica (t=1) del virus mvm, vp1 y vp2,  pueden ser entrecruzadas con el agente qu\u00edmico dimetil-suberimidato en dos olig\u00f3meros equimoleculares. La especie de mayor tama\u00f1o presenta vp1 y corresponde en tama\u00f1o (200kda) a un heterotr\u00edmero formado por una subunidad de vp1 y dos de vp2. El olig\u00f3mero de menor tama\u00f1o contiene s\u00f3lo vp2 y corresponde en tama\u00f1o (180 kda) a un homotr\u00edmero de esta prote\u00edna. La introducci\u00f3n de mutaciones en residuos involucrados en m\u00faltiples interacciones en las interfases entre tr\u00edmeros de vps en la c\u00e1psida de mvm produce la acumulaci\u00f3n de intermedios trim\u00e9ricos competentes para el transporte al n\u00facleo pero no para ensamblar en c\u00e1psidas. Por otro lado, mutaciones en los residuos b\u00e1sicos en la se\u00f1al de localizaci\u00f3n nuclear de estas prote\u00ednas (motivo de localizaci\u00f3n nuclear, nlm) , inactivan su funci\u00f3n y producen la acumulaci\u00f3n citoplasm\u00e1tica de las prote\u00ednas. La mutaci\u00f3n de la se\u00f1al nlm produc\u00eda la acumulaci\u00f3n de los trimeros de vp2 en el citoplasma, mientras que los heterotr\u00edmeros que contienen vp1 se localizan fundamentalmente en el n\u00facleo. Estos resultados indican que el ensamblaje de la c\u00e1psida del virus mvm ocurre a trav\u00e9s de intermedios trim\u00e9ricos en el citoplasma y que son competentes para translocarse a trav\u00e9s de la membrana nuclear. adem\u00e1s, cuando los trimeros que contienen vp1 son los \u00fanicos que se transportan al n\u00facleo, como ocurre en el mutante en el motivo nlm,  su ensamblaje produce la formaci\u00f3n de grandes agregados no regulares, lo que sugiere que la estequiometr\u00eda del transporte al n\u00facleo de ambos tipos de tr\u00edmeros act\u00faa como control de calidad durante la morfog\u00e9nesis viral.  adem\u00e1s, se analiz\u00f3 el transporte al n\u00facleo de tr\u00edmeros de prote\u00edna  vp<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ensamblaje de la c\u00e1psida del parvovirus mvm: transporte nuclear de intermedios trim\u00e9ricos y su regulaci\u00f3n por fosforilaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ensamblaje de la c\u00e1psida del parvovirus mvm: transporte nuclear de intermedios trim\u00e9ricos y su regulaci\u00f3n por fosforilaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Riolobos Santamar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Almendral Del Rio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Ortin monton <\/li>\n<li>eleuterio Lombardo de la camara (vocal)<\/li>\n<li>Rafael Blasco (vocal)<\/li>\n<li>\u00e1ngel Lopez carrascosa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Riolobos Santamar\u00eda Se ha investigado la regulaci\u00f3n del transporte nuclear de las prote\u00ednas estructurales de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[59094,116524,15326,14725,116523,116525],"class_list":["post-52810","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-angel-lopez-carrascosa","tag-eleuterio-lombardo-de-la-camara","tag-jose-maria-almendral-del-rio","tag-juan-ortin-monton","tag-laura-riolobos-santamaria","tag-rafael-blasco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=52810"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52810\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=52810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=52810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=52810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}