{"id":52859,"date":"2006-01-06T00:00:00","date_gmt":"2006-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-la-subunidad-reguladora-de-pi3k-p85-alfa-en-citoquinesis-en-mamiferos\/"},"modified":"2006-01-06T00:00:00","modified_gmt":"2006-01-06T00:00:00","slug":"funcion-de-la-subunidad-reguladora-de-pi3k-p85-alfa-en-citoquinesis-en-mamiferos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/funcion-de-la-subunidad-reguladora-de-pi3k-p85-alfa-en-citoquinesis-en-mamiferos\/","title":{"rendered":"Funcion de la subunidad reguladora de pi3k, p85 alfa, en citoquinesis en mamiferos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Zaira Garcia Fernandez <\/strong><\/h2>\n<p>Cytosolic division in mitotic cells involves the function of a number of proteins, whose coordination in the spatio-temporal control of cytokinesis is poorly defined. Cytokinesis requires cooperation of the tubulin, actomyosin, and septin cytoskeletons.  pi3k plays a crucial role in triggering cell division. Pi3k induces two routes, of which one promotes cell growth and the other regulates cyclin dependent kinases. Fine tuned pi3k regulation is also require for later cell cycle phases.  we analyzed the mechanism by which p85 alpha regulates cytokinesis, and show that p85 alpha deletion reduced cdc42 activation and septin 2 accumulation in the  cleavage furrow. The results show that p85 alpha affects cytokinesis by controlling local cdc42 activation and septin concentration in the cleavage furrow, revealing a new signalling cascade in the spatial control of mammalian cytokinesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion de la subunidad reguladora de pi3k, p85 alfa, en citoquinesis en mamiferos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion de la subunidad reguladora de pi3k, p85 alfa, en citoquinesis en mamiferos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Zaira Garcia Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Clara Carrera Ram\u00edrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Avila <\/li>\n<li>guillermo De carcer diez (vocal)<\/li>\n<li>Jes\u00fas Paramio (vocal)<\/li>\n<li>cristina Murga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Zaira Garcia Fernandez Cytosolic division in mitotic cells involves the function of a number of proteins, whose [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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