{"id":5287,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/identificacion-de-los-factores-paracrinos-responsables-de-la-destruccion-osea-en-el-colesteatoma-del-oido-medio\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"identificacion-de-los-factores-paracrinos-responsables-de-la-destruccion-osea-en-el-colesteatoma-del-oido-medio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/identificacion-de-los-factores-paracrinos-responsables-de-la-destruccion-osea-en-el-colesteatoma-del-oido-medio\/","title":{"rendered":"Identificacion de los factores paracrinos responsables de la destruccion osea en el colesteatoma del oido medio."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Placido Ostos Aumente <\/strong><\/h2>\n<p>La otitis media cronica colesteomatosa es una enfermedad inflamatoria caracterizada por la presencia de un epitelio hiperproliferativo en las cavidades del oido medio que conlleva a la destruccion osea. Este proceso estaria mediado por una serie de factores paracrinos (citocinas), producidas por los propios queratinocitos y por celulas inflamatorias, que actuarian sobre las celulas responsables de la destruccion osea (osteoclastos). Mediante tecnicas inmunohistoquimicas (inmunoperoxidasa indirecta, peroxidasa anti peroxidasa y fosfatasa alcalina anti fosfatasa alcalina) se procede a la identificacion de dichas citocinas (il-1, il-6, tnf, gm-csf, tgf) y alguno de sus receptores en el epitelio y estroma colesteomatoso. Posteriormente, mediante tecnicas de onmunoenzimoensayo, se cuantifica la concentracion de las citocinas, encontrando concentraciones muy superiores en las muestras de colesteatoma en relacion con las de piel. Por ultimo, se determina la actividad biologica de la interlucina-1 y la interlucina-6 mediante lineas celulares, observando una mayor actividad biologica en las muestras de colesteatoma debido a su mayor concentracion (ya que a identicas concentraciones presentan similares actividades biologicas).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificacion de los factores paracrinos responsables de la destruccion osea en el colesteatoma del oido medio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificacion de los factores paracrinos responsables de la destruccion osea en el colesteatoma del oido medio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Placido Ostos Aumente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Lopez Villarejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eugenio Arevalo Jimenez <\/li>\n<li>Francisco Esteban Ortega (vocal)<\/li>\n<li>Francisco Mu\u00f1oz Borges (vocal)<\/li>\n<li>Juan Bartual Pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Placido Ostos Aumente La otitis media cronica colesteomatosa es una enfermedad inflamatoria caracterizada por la presencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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