{"id":52936,"date":"2006-06-06T00:00:00","date_gmt":"2006-06-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-intercambiador-de-sodio-hidrogeno-en-la-lesion-por-isquemia-reperfusion-miocardica-y-cerebral\/"},"modified":"2006-06-06T00:00:00","modified_gmt":"2006-06-06T00:00:00","slug":"influencia-del-intercambiador-de-sodio-hidrogeno-en-la-lesion-por-isquemia-reperfusion-miocardica-y-cerebral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-del-intercambiador-de-sodio-hidrogeno-en-la-lesion-por-isquemia-reperfusion-miocardica-y-cerebral\/","title":{"rendered":"Influencia del intercambiador de sodio-hidr\u00f3geno en la lesi\u00f3n por isquemia-reperfusi\u00f3n mioc\u00e1rdica y cerebral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Castell\u00e1 Peric\u00e1s <\/strong><\/h2>\n<p>El intercambiador de sodio-hidr\u00f3geno (nhe) participa activamente en los procesos de lesi\u00f3n celular derivados de las interrupci\u00f3n temporal de la perfusi\u00f3n tisular. El bloqueo de este intercambiador antes del inicio de la isquemia disminuye el da\u00f1o directo mioc\u00e1rdico y endotelial en los modelos de isquemia-reperfusi\u00f3n. Mediciones directas del efecto del nhe son el grado de edema, significativamente mayor en los animales sin bloqueo del intercambiador. Pero tambi\u00e9n en marcadores de lesi\u00f3n mioc\u00e1rdica como ck-mb se detectaron importantes diferencias. Y, por encima de todo, la funci\u00f3n contr\u00e1ctil mioc\u00e1rdica se vio severamente afectada sin el nhe no se bloqueaba con cariporide. Para nuestra sorpresa, tambi\u00e9n otros indicadores de lesi\u00f3n de isquemia-reperfusi\u00f3n m\u00e1s enfocados a otros mecanismos fueron tambi\u00e9n influenciados por la inhibici\u00f3n del nhe. Marcadores de peroxidaci\u00f3n lip\u00eddica dependiente de lesi\u00f3n por radicales libres, medido a trav\u00e9s de la concentraci\u00f3n de enlaces conjugados en plasma, o los niveles tisulares de mieloperoxidas, dependiente de la adhesi\u00f3n y activaci\u00f3n leucocitaria, fueron significativamente mayores en los corazones con nhe activo. Por tanto, la influencia del nhe en la lesi\u00f3n por isquemia-reperfusi\u00f3n debe ser importante en los primeros estadios de la cascada de acontecimientos celulares que derivan tanto en la producci\u00f3n de radicales libres, como en la acumulaci\u00f3n de calcio, los dos reconocidos motores responsables del da\u00f1o por reperfusi\u00f3n.  cuando la inhibici\u00f3n del nhe se realiz\u00f3 durante la reperfusi\u00f3n controlada, la preservaci\u00f3n funcional mioc\u00e1rdica fue mucho mayor que si no se hubiese bloqueado el intercambiador. Pese a que el nhe juega un papel fundamental en la lesi\u00f3n por reperfusi\u00f3n, y que su activaci\u00f3n principal durante la isquemia sea debida a la acidosis anaer\u00f3bica, el tratamiento espec\u00edfico mediante reperfusi\u00f3n alcal\u00f3tica no parece influir en la recuperaci\u00f3n de los coraz<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del intercambiador de sodio-hidr\u00f3geno en la lesi\u00f3n por isquemia-reperfusi\u00f3n mioc\u00e1rdica y cerebral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del intercambiador de sodio-hidr\u00f3geno en la lesi\u00f3n por isquemia-reperfusi\u00f3n mioc\u00e1rdica y cerebral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Castell\u00e1 Peric\u00e1s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>prats Pomar Moya<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Gomar sancho <\/li>\n<li>david Garc\u00eda dorado (vocal)<\/li>\n<li>gines Sanz romero (vocal)<\/li>\n<li>pilar Tornos mas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Castell\u00e1 Peric\u00e1s El intercambiador de sodio-hidr\u00f3geno (nhe) participa activamente en los procesos de lesi\u00f3n celular derivados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,932,9,141,2189,139],"tags":[11498,83960,11774,116817,1166,116818],"class_list":["post-52936","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-cardiologia","category-ciencias-medicas","category-cirugia","category-cirugia-cardiaca","category-medicina-interna","tag-carmen-gomar-sancho","tag-david-garcia-dorado","tag-gines-sanz-romero","tag-manuel-castella-pericas","tag-pilar-tornos-mas","tag-prats-pomar-moya"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=52936"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52936\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=52936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=52936"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=52936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}