{"id":52940,"date":"2006-06-06T00:00:00","date_gmt":"2006-06-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-protea%c2%adna-bcrp-abcp-abcg2-en-el-transporte-y-aparicion-de-farmacos-en-leche-expresion-y-modulacion-funcional-en-rumiantes\/"},"modified":"2006-06-06T00:00:00","modified_gmt":"2006-06-06T00:00:00","slug":"implicacion-de-la-protea%c2%adna-bcrp-abcp-abcg2-en-el-transporte-y-aparicion-de-farmacos-en-leche-expresion-y-modulacion-funcional-en-rumiantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-accion-de-los-farmacos\/implicacion-de-la-protea%c2%adna-bcrp-abcp-abcg2-en-el-transporte-y-aparicion-de-farmacos-en-leche-expresion-y-modulacion-funcional-en-rumiantes\/","title":{"rendered":"Implicaci\u00f3n de la prote\u00edna bcrp\/abcp\/abcg2 en el transporte y aparici\u00f3n de f\u00e1rmacos en leche. expresi\u00f3n y modulaci\u00f3n funcional en rumiantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pulido Duarte Mivis Mildrey <\/strong><\/h2>\n<p>La importancia de los residuos de f\u00e1rmacos en leche y su control, se manifiesta en la actuaci\u00f3n de la agencia europea de medicamentos, que recoge en su normativa los l\u00edmites m\u00e1ximos de residuos permitidos para f\u00e1rmacos usados tanto en la prevenci\u00f3n como en el tratamiento de diversas parasitosis o infecciones (antes y\/o durante la lactaci\u00f3n),  en el ganado ovino y bovino. Los transportadores abc son prote\u00ednas que act\u00faan como bombas exportadoras dependientes de atp que sacan activamente hacia el exterior de la c\u00e9lula  tanto f\u00e1rmacos, como metabolitos end\u00f3genos y xenotoxinas,  estando involucrados en el fen\u00f3meno de multirresistencia de f\u00e1rmacos.  se ha descrito la presencia de estas prote\u00ednas en diferentes \u00f3rganos entre los que se encuentran h\u00edgado, cerebro, ri\u00f1\u00f3n, intestino y la gl\u00e1ndula mamaria. La transferencia de f\u00e1rmacos hacia la leche ocurre fundamentalmente por difusi\u00f3n pasiva pero determinados f\u00e1rmacos, en los que se han descrito elevados niveles en leche (valores por encima de los esperados en procesos \u00fanicamente mediados por mecanismos pasivos),  pueden depender, de sistemas  activos de transporte hacia la leche.  teniendo en cuenta estas premisas, determinamos la expresi\u00f3n funcional de la bcrp, una prote\u00edna de tipo abc, que exporta f\u00e1rmacos, en diferentes tejidos de rumiantes, sobre todo en gl\u00e1ndula mamaria en distintos estadios de lactaci\u00f3n, tanto en ovejas como en vacas.  Realizamos estudios in vitro con l\u00edneas celulares establecidas para determinar la implicaci\u00f3n de la bcrp en el transporte de albendazol sulf\u00f3xido, enrofloxacina y moxidectina (todos ellos f\u00e1rmacos de amplio uso en veterinaria)  y se estudi\u00f3 la correlaci\u00f3n entre los experimentos in vitro e in vivo,  mediante estudios f\u00e1rmacocin\u00e9ticos, en presencia de diferentes moduladores del transporte mediado por la prote\u00edna bcrp.  los estudios inmunohistoqu\u00edmicos y por western blot realizados demostraron la expresi\u00f3n diferencial de la bcrp en la gl\u00e1ndula mama<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la prote\u00edna bcrp\/abcp\/abcg2 en el transporte y aparici\u00f3n de f\u00e1rmacos en leche. expresi\u00f3n y modulaci\u00f3n funcional en rumiantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la prote\u00edna bcrp\/abcp\/abcg2 en el transporte y aparici\u00f3n de f\u00e1rmacos en leche. expresi\u00f3n y modulaci\u00f3n funcional en rumiantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pulido Duarte Mivis Mildrey <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Prieto Fernandez Julio Gabriel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Planas rosell\u00f3 joana Mar\u00eda <\/li>\n<li>Miguel angel Bregante ucedo (vocal)<\/li>\n<li>matilde Sierra vega (vocal)<\/li>\n<li>carmen Mar\u00eda Vazquez cueto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pulido Duarte Mivis Mildrey La importancia de los residuos de f\u00e1rmacos en leche y su control, se 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