{"id":52973,"date":"2006-08-06T00:00:00","date_gmt":"2006-08-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mieloma-multiple-quiescente-historia-natural-y-caracterizacion-cla%c2%adnica-y-citogenetica-del-tipo-progresivo\/"},"modified":"2006-08-06T00:00:00","modified_gmt":"2006-08-06T00:00:00","slug":"mieloma-multiple-quiescente-historia-natural-y-caracterizacion-cla%c2%adnica-y-citogenetica-del-tipo-progresivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/mieloma-multiple-quiescente-historia-natural-y-caracterizacion-cla%c2%adnica-y-citogenetica-del-tipo-progresivo\/","title":{"rendered":"Mieloma m\u00faltiple quiescente: historia natural y caracterizaci\u00f3n cl\u00ednica y citogen\u00e9tica del tipo progresivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Rosi\u00f1ol Dachs <\/strong><\/h2>\n<p>El mieloma quiescente (mq) se caracteriza porque los pacientes cumplen los criterios diagn\u00f3sticos de mieloma m\u00faltiple (mm) pero est\u00e1n asintom\u00e1ticos. Sin embargo, todos los pacientes acaban progresando a un mm sintom\u00e1tico y requieren tratamiento, con un tiempo mediano hasta la progresi\u00f3n de entre 1 y 3 a\u00f1os. No obstante, el tiempo hasta la progresi\u00f3n es muy variable de unos pacientes a otros, y mientras unos progresan al cabo de unos pocos meses tras el diagn\u00f3stico otros permanecen estables durante 5 \u00f3 10 a\u00f1os. Por este motivo, resulta de gran inter\u00e9s identificar los pacientes que van a presentar una progresi\u00f3n r\u00e1pida y que eventualmente podr\u00edan beneficiarse de un tratamiento precoz, en este sentido, las alteraciones citogen\u00e9ticas son un factor pron\u00f3stico fundamental en el mm. Las nuevas tecnolog\u00edas como la hibridaci\u00f3n gen\u00f3mica comparada (hgc) permiten estudiar neoplasias con un bajo \u00edndice mit\u00f3tico, como el mq, en las que l citogen\u00e9tica convencional obtiene un rendimiento muy bajo debido a la ausencia de metafase.     en este contexto, los objetivos dela presente tesis fueron estudiar la historia natural del mq con el an\u00e1lisis de los par\u00e1metros cl\u00ednicos y de laboratorio predictivos de transformaci\u00f3n precoz, incluyendo la influencia pron\u00f3stica de las anomal\u00edas citogen\u00e9ticas estudiadas mediante el hgc.     en el primer trabajo que conforma esta tesis se identific\u00f3 por primera vez el mq de tipo \u00abprogresivo\u00bb, caracterizado, por un aumento continuado del componente m. Antecedente de gmsi, mayor frecuencia del tipo iga y r\u00e1pida evoluci\u00f3n mm sintom\u00e1tico. Por el contrario, el mq \u00abno progresivo\u00bb o cl\u00e1sico se caracteriza por un componente m que permanece estable hasta el momento de la transformaci\u00f3n, ausencia casi constante de gmsi previa y progresi\u00f3n m\u00e1s tard\u00eda a mm sontom\u00e1tico. El patr\u00f3n de progresi\u00f3n del mq consiste en anemia y\/u ote\u00f3lisis en ausencia de insuficiencia renal, hipercalcemia o plasmocitomas extramedulares, por o<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mieloma m\u00faltiple quiescente: historia natural y caracterizaci\u00f3n cl\u00ednica y citogen\u00e9tica del tipo progresivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mieloma m\u00faltiple quiescente: historia natural y caracterizaci\u00f3n cl\u00ednica y citogen\u00e9tica del tipo progresivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Rosi\u00f1ol Dachs <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Blade Creixenti<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cirilo Rozman borsmar <\/li>\n<li>evarist Feliu frasnedo (vocal)<\/li>\n<li>a. Kyle robert (vocal)<\/li>\n<li>Jes\u00fas Fernando San Miguel izquierdo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Rosi\u00f1ol Dachs El mieloma quiescente (mq) se caracteriza porque los pacientes cumplen los criterios diagn\u00f3sticos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,218],"tags":[116897,197,13790,9596,38198,116896],"class_list":["post-52973","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-hematologia","tag-a-kyle-robert","tag-cirilo-rozman-borsmar","tag-evarist-feliu-frasnedo","tag-jesus-fernando-san-miguel-izquierdo","tag-joan-blade-creixenti","tag-laura-rosinol-dachs"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=52973"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/52973\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=52973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=52973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=52973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}