{"id":52978,"date":"2006-08-06T00:00:00","date_gmt":"2006-08-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-tratamientos-contra-la-obesidad-desarrollo-de-antagonistas-del-receptor-cannabinoide-cb1-y-agonistas-del-receptor-nuclear-ppar-alfa\/"},"modified":"2006-08-06T00:00:00","modified_gmt":"2006-08-06T00:00:00","slug":"nuevos-tratamientos-contra-la-obesidad-desarrollo-de-antagonistas-del-receptor-cannabinoide-cb1-y-agonistas-del-receptor-nuclear-ppar-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/nuevos-tratamientos-contra-la-obesidad-desarrollo-de-antagonistas-del-receptor-cannabinoide-cb1-y-agonistas-del-receptor-nuclear-ppar-alfa\/","title":{"rendered":"Nuevos tratamientos contra la obesidad: desarrollo de antagonistas del receptor cannabinoide cb1 y agonistas del receptor nuclear ppar alfa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Pav\u00f3n Mor\u00f3n <\/strong><\/h2>\n<p>La obesidad es un trastorno metab\u00f3lico y nutricional debido a un desequilibrio energ\u00e9tico en el que el consumo de energ\u00eda supera al gasto y resulta en un excesivo almacenamiento de energ\u00eda en forma de tejido adiposo, lo que supone un riesgo para la salud. La regulaci\u00f3n de la ingesta de alimentos es fundamental para el mantenimiento de la homeostasis energ\u00e9tica, existiendo una gran cantidad de se\u00f1ales de apetito y saciedad que informan sobre el estado energ\u00e9tico del organismo. entre estas se\u00f1ales esta tesis se centra en las aciletanolamidas, destacando dos de sus integrantes: anandamida (aea) y oleiletanolamida (oea), por su papel coordinado sobre la ingesta de comida, el metabolismo energ\u00e9tico y la variaci\u00f3n de peso corporal. La aea es un compuesto orexig\u00e9nico a trav\u00e9s de la activaci\u00f3n del receptor cannabionide cb1 mientras que la oea es un factor de saciedad a trav\u00e9s de la activaci\u00f3n del receptor nuclear ppar alfa. Por tanto el desarrollo de compuestos activadores (agonistas) de ppar alfa y de bloqueadores (bien antagonistas neutrales o agonistas inversos) de cb1 podr\u00edan resultar interesantes en el tratamiento de des\u00f3rdenes alimentarios como la obesidad.     para la realizaci\u00f3n de esta tesis se ha optado por desarrollar dos l\u00edneas de trabajo paralelas centradas:    1 ,- caracterizar en ingesta un anatagonista neutral triaz\u00f3lico del receptor cannabionoide cb1, sin propiedades de agonismo inverso denominado lh-21 empleando un bloqueador de referencia sr-141716 a ampliamente caracterizado.     2,- identificar y caracterizar en ingesta an\u00e1logos estructurales sulfamidas de aciletanolamidas como la oea.     los resultados han arrojado las siguientes conclusiones en ambos bloques experimentales:     a,- el compuesto lh-21 presenta un perfil de actuaci\u00f3n en ingesta diferente a sr-141716a:     * lh-21 muestra una potencia similar a sr-1417161a en la reducci\u00f3n de ingesta de comida y ganancia de peso corporal incluso en modelos de obesidad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos tratamientos contra la obesidad: desarrollo de antagonistas del receptor cannabinoide cb1 y agonistas del receptor nuclear ppar alfa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos tratamientos contra la obesidad: desarrollo de antagonistas del receptor cannabinoide cb1 y agonistas del receptor nuclear ppar alfa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Pav\u00f3n Mor\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Rodriguez De Fonseca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Fernandez llebrez del rey <\/li>\n<li> Arco y herrera ignacio del (vocal)<\/li>\n<li>pilar Goya laza (vocal)<\/li>\n<li> Villan\u00faa bernues Mar\u00eda angeles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Pav\u00f3n Mor\u00f3n La obesidad es un trastorno metab\u00f3lico y nutricional debido a un desequilibrio energ\u00e9tico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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