{"id":52987,"date":"2006-08-06T00:00:00","date_gmt":"2006-08-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesi-enantioselectiva-de-compostos-ciclohexa-nics-polioxigenats-trans-2-ciclohexen-14-diol-i-gabosines\/"},"modified":"2006-08-06T00:00:00","modified_gmt":"2006-08-06T00:00:00","slug":"sa%c2%adntesi-enantioselectiva-de-compostos-ciclohexa-nics-polioxigenats-trans-2-ciclohexen-14-diol-i-gabosines","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sa%c2%adntesi-enantioselectiva-de-compostos-ciclohexa-nics-polioxigenats-trans-2-ciclohexen-14-diol-i-gabosines\/","title":{"rendered":"S\u00edntesi enantioselectiva de compostos ciclohex\u00c1\u00a0nics polioxigenats. trans-2-ciclohexen-1,4-diol i gabosines"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Georgina Marjanet Artigas <\/strong><\/h2>\n<p>La naturaleza sintetiza una gran variedad de mol\u00e9culas que contienen un anillo de ciclohexano muy funcionalizado con uno o varios centros estereog\u00e9nicos y que poseen una amplia gama de actividades biol\u00f3gicas.  dentro del proyecto de s\u00edntesis enantioselectiva de ciclohexanos polifuncionalizados, utilizando el monoacetal enantiopuro de la p-benzoquinona 10-feniltio-1,4-dioxaespiro[4.5]dec-6-en-8-ona, 1, como sustrato de partida se han sintetizado una gran variedad de intermedios clave, tanto en forma rac\u00e9mica como enantiopura, que nos permiten abordar la s\u00edntesis de distintos productos naturales de inter\u00e9s biol\u00f3gico.  en primer lugar se ha desarrollado la s\u00edntesis de cada uno de los enanti\u00f3meros de trans-2-ciclohexen-1,4-diol. Su obtenci\u00f3n en nuestros laboratorios con un elevado exceso enantiom\u00e9rico y buen rendimiento supone un nuevo m\u00e9todo de preparaci\u00f3n de este compuesto.  las gabosinas son una familia de metabolitos secundarios estructuralmente muy relacionados entre s\u00ed que han sido aislados de diferentes cepas de sreptomyces. Estos compuestos presentan un sistema de metilciclohexano, como esqueleto carbonado com\u00fan y varios \u00e1tomos de ox\u00edgeno como sustituyentes. entre las actividades biol\u00f3gicas descritas para algunas gabosinas, as\u00ed como otros productos naturales relacionados, se encuentran: efecto regulador del crecimiento de plantas, propiedades de anclaje al adn, actividad antibacteriana, inhibici\u00f3n de glicosidasas y glioxilasa-i (y por tanto una potencial acci\u00f3n anticancer\u00edgena selectiva frente a determinados tumores), actividad antiprotozoica, etc. Debido a su peculiar estructura y prometedora actividad biol\u00f3gica se han desarrollado s\u00edntesis de algunas gabosinas, pero el dise\u00f1o de una aproximaci\u00f3n general mediante una metodolog\u00eda sint\u00e9tica flexible que permitiera acceder al mayor n\u00famero de posible de estos compuestos partiendo de un intermedio com\u00fan es todav\u00eda un terreno inexplorado.  se ha dise\u00f1ado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesi enantioselectiva de compostos ciclohex\u00c1\u00a0nics polioxigenats. trans-2-ciclohexen-1,4-diol i gabosines<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesi enantioselectiva de compostos ciclohex\u00c1\u00a0nics polioxigenats. trans-2-ciclohexen-1,4-diol i gabosines <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Georgina Marjanet Artigas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Figueredo Galimany<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Castedo exposito <\/li>\n<li> Peric\u00ed\u00a0s brondo Miguel angel (vocal)<\/li>\n<li>Jos\u00e9 joaquin Barluenga mur (vocal)<\/li>\n<li>albert Moyano baldoire (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Georgina Marjanet Artigas La naturaleza sintetiza una gran variedad de mol\u00e9culas que contienen un anillo de ciclohexano [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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