{"id":53010,"date":"2006-09-06T00:00:00","date_gmt":"2006-09-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-isquemia-reperfusion-interstinal-en-la-absorcion-y-en-el-metabolismo-de-albendazol-y-diltiazem\/"},"modified":"2006-09-06T00:00:00","modified_gmt":"2006-09-06T00:00:00","slug":"efecto-de-la-isquemia-reperfusion-interstinal-en-la-absorcion-y-en-el-metabolismo-de-albendazol-y-diltiazem","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacos-psicotropicos\/efecto-de-la-isquemia-reperfusion-interstinal-en-la-absorcion-y-en-el-metabolismo-de-albendazol-y-diltiazem\/","title":{"rendered":"Efecto de la isquemia-reperfusion interstinal en la absorci\u00f3n y en el metabolismo de albendazol y diltiazem"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Jose Molina De La Torre <\/strong><\/h2>\n<p>La isquemia-reperfusi\u00f3n (i\/r) intestinal est\u00e1 considerado un problema cl\u00ednico con elevada mortalidad y un aumento en su incidencia durante los \u00faltimos a\u00f1os. Los da\u00f1os causados incluyen la formaci\u00f3n de radicales libres, la liberaci\u00f3n de citoquinas y graves alteraciones en la mucosa intestinal. Puesto que el intestino tiene gran influencia en la biodisponibilidad de f\u00e1rmacos administrados oralmente, tanto por los procesos absortivos como por la acci\u00f3n de los sistemas de detoxificaci\u00f3n presentes, se evalu\u00f3 el efecto que la isquemia-reperfusi\u00f3n tiene en la absorci\u00f3n y en el metabolismo de albendazol (abz) y diltiazem (dtz), dos f\u00e1rmacos que son administrados oralmente y presentan un importante metabolismo intestinal. El proceso de i\/r fue generado por la oclusi\u00f3n de la arteria mesent\u00e9rica superior y la posterior reperfusi\u00f3n en ratas, realiz\u00e1ndose estudios in situ, con microsomas intestinales y anillos evertidos de yeyuno e ileon.  los resultados obtenidos en los estudios in situ muestran que la captaci\u00f3n de abz desde el lumen y su aparici\u00f3n en sangre fueron incrementadas por la i\/r intestinal, reduci\u00e9ndose adem\u00e1s la formaci\u00f3n del metabolito albendazol sulf\u00f3xido (abzso). Los estudios con anillos evertidos y con microsomas intestinales confirman una menor actividad albendazol sulfoxidasa, demostr\u00e1ndose que son afectados los sistemas fmo y cyp3a responsables de dicha actividad.    los estudios in situ con dtz, mostraron que tras la i\/r aumenta la aparici\u00f3n en sangre del f\u00e1rmaco respecto a lo observado en el grupo control, reduci\u00e9ndose la formaci\u00f3n total de metabolitos, de los cuales el desacetildiltiazem (m1) generado por las esterasas fue el metabolito mayoritario. Los estudios con microsomas mostraron un descenso de la formaci\u00f3n de m1, tras la i\/r, observ\u00e1ndose que dicha actividad es inhibida por paraoxon y bis-nitrofenilfosfato. En los estudios con anillos evertidos tambi\u00e9n se observ\u00f3 un descenso en la formaci\u00f3n de metabolitos tras i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la isquemia-reperfusion interstinal en la absorci\u00f3n y en el metabolismo de albendazol y diltiazem<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la isquemia-reperfusion interstinal en la absorci\u00f3n y en el metabolismo de albendazol y diltiazem <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Jose Molina De La Torre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Prieto Fernandez  Julio Gabriel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lu\u00eds Palacios raufast <\/li>\n<li> Rodriguez yolodi M\u00aa Jes\u00fas (vocal)<\/li>\n<li>adela Mart\u00edn villodr\u00e9 (vocal)<\/li>\n<li>Ana Sola Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Jose Molina De La Torre La isquemia-reperfusi\u00f3n (i\/r) intestinal est\u00e1 considerado un problema cl\u00ednico con elevada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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