{"id":53059,"date":"2006-12-06T00:00:00","date_gmt":"2006-12-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-tumorales-en-la-prediccion-de-metastasis-en-el-cancer-escamoso-de-cabeza-y-cuello\/"},"modified":"2006-12-06T00:00:00","modified_gmt":"2006-12-06T00:00:00","slug":"marcadores-tumorales-en-la-prediccion-de-metastasis-en-el-cancer-escamoso-de-cabeza-y-cuello","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-tumorales-en-la-prediccion-de-metastasis-en-el-cancer-escamoso-de-cabeza-y-cuello\/","title":{"rendered":"Marcadores tumorales en la prediccion de metastasis en el cancer escamoso de cabeza y cuello"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Al Kassam Martinez Daniel <\/strong><\/h2>\n<p>El c\u00e1ncer escamoso de cabeza y cuello (cecc) constituye un problema socio-sanitario de gran relevancia al presentarse todos los a\u00f1os 500.000 casos nuevos en todo el mundo. Este tumor epitelial tiene una alta incidencia en espa\u00f1a donde alcanza los 24 casos\/100.000 habitantes\/a\u00f1o con una tendencia ascendente. las principales causas de mortalidad se deben a la recidiva local y sobre todo a las met\u00e1stasis ganglionares. En la actualidad no existe un marcador tumoral s\u00e9rico, espec\u00edfico para este tipo de tumores, que sea capaz de predecir pre-operatoriamente el desarrollo de met\u00e1stasis regionales o a distancia.  objetivos: este estudio presenta dos objetivos fundamentales, por un lado la b\u00fasqueda de un patr\u00f3n espec\u00edfico  de cecc, combinando varios marcadores tumorales s\u00e9ricos, que consiga superar las limitaciones de los marcadores actuales. Por otro lado, intentar predecir, antes de tomar una actitud terap\u00e9utica, la evoluci\u00f3n de la enfermedad, utilizando marcadores directamente relacionados con la capacidad de invasi\u00f3n local y la diseminaci\u00f3n metast\u00e1sica.  material y m\u00e9todos: se tomar\u00e1n muestras de suero a 39  pacientes con cecc de forma preoperatoria, determinando el valor de los distintos marcadores tumorales  por medio de t\u00e9cnicas de elisa, y quimioluminiscencia. Se tomaron como control 10 muestras procedentes del banco de sangre del pricipado de asturias.   Los marcadores seleccionados para establecer el perfil espec\u00edfico de cecc fueron: agscc, anticuerpos anti-p53 y cyfra 21.1; siendo los marcadores seleccionados en relaci\u00f3n a la agresividad tumoral (invasi\u00f3n local y met\u00e1stasis): e-cadherina y metaloproteasas (mmp-2, mmp-9 y mmp-13 activa).  resultados: se encontraron diferencias significativas entre las concentraciones de cyfra21.1, e-cadherina,, mmp-9, mmp-13 activada y anticuerpos anti-p53 de controles y de pacientes con cecc. Las concentraciones de cyfra 21.1 y  la presencia de ac antip-53 variaron de forma es<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores tumorales en la prediccion de metastasis en el cancer escamoso de cabeza y cuello<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores tumorales en la prediccion de metastasis en el cancer escamoso de cabeza y cuello <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Al Kassam Martinez Daniel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Llorente Pendas Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suarez nieto <\/li>\n<li>primitivo Ortega  del alamo (vocal)<\/li>\n<li> Alvarez menendez Francisco vicente (vocal)<\/li>\n<li> Gonzalez gonzalez Juan  Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Al Kassam Martinez Daniel El c\u00e1ncer escamoso de cabeza y cuello (cecc) constituye un problema socio-sanitario de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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