{"id":53060,"date":"2006-12-06T00:00:00","date_gmt":"2006-12-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/galectina-3-como-marcador-en-los-nodulos-tiroideos\/"},"modified":"2006-12-06T00:00:00","modified_gmt":"2006-12-06T00:00:00","slug":"galectina-3-como-marcador-en-los-nodulos-tiroideos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/galectina-3-como-marcador-en-los-nodulos-tiroideos\/","title":{"rendered":"Galectina 3 como marcador en los nodulos tiroideos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alvarez Zapico Mar\u00eda  Jes\u00fas <\/strong><\/h2>\n<p>Introducci\u00f3n: los n\u00f3dulos tiroideos est\u00e1n presentes en el 4-7% de la poblaci\u00f3n. aunque la mayor\u00eda de estas lesiones son benignas, aproximadamente el 10% corresponden a neoplasias malignas.En el manejo cl\u00ednico del n\u00f3dulo tiroideo la prueba diagn\u00f3stica considerada actualmente de m\u00e1s utilidad es el an\u00e1lisis morfol\u00f3gico de las c\u00e9lulas tiroideas obtenidas mediante paaf, pero tiene importantes limitaciones, sobre todo en el diagn\u00f3stico diferencial de lesiones foliculares. Por ello, en los \u00faltimos a\u00f1os se ha intentado incrementar su rendimiento mediante el estudio de marcadores de malignidad que aumenten su exactitud diagn\u00f3stica evitando tiroidectom\u00edas innecesarias. Varios estudios han sugerido la galectina-3 como uno de estos marcadores.  objetivos: determinar la utilidad de la galectina-3 como un marcador fiable de malignidad en el diagn\u00f3stico diferencial de los n\u00f3dulos tiroideos tanto a nivel preoperatorio en muestras citol\u00f3gicas obtenidad mediante paaf como en muestras histol\u00f3gicas.  metodolog\u00eda: se analizaron retrospectivamente 239 muestras parafinadas tiroideas procedentes de pacientes intervenidos quir\u00fargicamente que corresponden a 69 casos de tejido tiroideo normal, 95 lesiones benignas y 75 malignas. prospectivamente se estudiaron 92 muestras citol\u00f3gicas obtenidas mediante paaf (10 casos de tejido tiroideo normal, 50 lesiones benignas y 32 malignas). mediante t\u00e9cnicas de inmonocitoqu\u00edmica se analiz\u00f3 la expresi\u00f3n de galectina-3 y se calcularon la sensibilidad y especificidad de la misma como m\u00e9todo diagn\u00f3stico en la diferenciaci\u00f3n de lesiones benignas y malignas en muestras histol\u00f3gicas y citol\u00f3gicas.  resultados: en el estudio histol\u00f3gico el 95% de los carcinomas expresaron galectina-3, mientras que el 91% de las lesiones benignas fueron negativas. la sensibilidad y especificidad obtenida fue del 97% y 94% respectivamente. en las muestras citol\u00f3gicas (paaf) la sensibilidad y especificidad en la difer<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Galectina 3 como marcador en los nodulos tiroideos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Galectina 3 como marcador en los nodulos tiroideos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alvarez Zapico Mar\u00eda  Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Llorente Pendas Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suarez nieto <\/li>\n<li>Jos\u00e9 Martinez vidal (vocal)<\/li>\n<li>primitivo Ortega  del alamo (vocal)<\/li>\n<li>david alonso Hardisson hernaez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvarez Zapico Mar\u00eda Jes\u00fas Introducci\u00f3n: los n\u00f3dulos tiroideos est\u00e1n presentes en el 4-7% de la poblaci\u00f3n. aunque [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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