{"id":53141,"date":"2018-03-09T22:40:48","date_gmt":"2018-03-09T22:40:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-los-mecanismos-moleculares-que-median-la-funcion-de-la-protea%c2%adna-gas1-a-traves-del-receptor-tirosina-quinasa-ret\/"},"modified":"2018-03-09T22:40:48","modified_gmt":"2018-03-09T22:40:48","slug":"identificacion-de-los-mecanismos-moleculares-que-median-la-funcion-de-la-protea%c2%adna-gas1-a-traves-del-receptor-tirosina-quinasa-ret","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/identificacion-de-los-mecanismos-moleculares-que-median-la-funcion-de-la-protea%c2%adna-gas1-a-traves-del-receptor-tirosina-quinasa-ret\/","title":{"rendered":"Identificaci\u00f3n de los mecanismos moleculares que median la funci\u00f3n de la prote\u00edna gas1 a trav\u00e9s del receptor tirosina quinasa  ret"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cabrera Heredia Jorge  Rub\u00e9n <\/strong><\/h2>\n<p>The growth arrest specific gene 1 (gas1) protein has been proposed to function during development as an inhibitor of growth and a mediator of cell death, and is also re-expressed in adult neurons during excitotoxic stimuli.  here we demonstrate that the gas1 protein shows high structural similarity to the gdnf (glial cell-derived neurotrophic factor) family receptors alpha, which mediate gdnf responses through the receptor tyrosine kinase ret. we found that gas1 binds ret in a ligand-independent manner and sequesters ret in lipid rafts.  signalling downstream of ret is thus modified through a mechanism that involves the adaptor protein shc as well as erk2, eventually blocking akt activation. Consequently, when gas1 is induced, ret-mediated gdnf-dependent survival effects are compromised.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de los mecanismos moleculares que median la funci\u00f3n de la prote\u00edna gas1 a trav\u00e9s del receptor tirosina quinasa  ret<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de los mecanismos moleculares que median la funci\u00f3n de la prote\u00edna gas1 a trav\u00e9s del receptor tirosina quinasa  ret <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cabrera Heredia Jorge  Rub\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Britt Mellstr\u00c1\u00b6m<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan xavier Comella carnice <\/li>\n<li>Francisco Wandosell (vocal)<\/li>\n<li>valent\u00edn Ce\u00f1a (vocal)<\/li>\n<li>mario Encinas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cabrera Heredia Jorge Rub\u00e9n The growth arrest specific gene 1 (gas1) protein has been proposed to function [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,17],"tags":[117279,117278,117280,41179,117282,117281],"class_list":["post-53141","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-quimica","tag-britt-mellstram","tag-cabrera-heredia-jorge-ruben","tag-francisco-wandosell","tag-joan-xavier-comella-carnice","tag-mario-encinas","tag-valentin-cena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=53141"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53141\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=53141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=53141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=53141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}