{"id":53181,"date":"2018-03-09T22:40:48","date_gmt":"2018-03-09T22:40:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citocinas-y-dano-oxidante-en-la-hepatitis-alcoholica\/"},"modified":"2018-03-09T22:40:48","modified_gmt":"2018-03-09T22:40:48","slug":"citocinas-y-dano-oxidante-en-la-hepatitis-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/citocinas-y-dano-oxidante-en-la-hepatitis-alcoholica\/","title":{"rendered":"Citocinas y da\u00f1o oxidante en la hepatitis alcoholica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sanchez Perez Mar\u00eda  Jose <\/strong><\/h2>\n<p>El consumo cr\u00f3nico de alcohol supone un problema socio-sanitario de primer orden. Esta sustancia puede afectar a la mayor\u00eda de \u00f3rganos de la econom\u00eda siendo la afectaci\u00f3n hep\u00e1tica la m\u00e1s importante. con este trabajo intentamos analizar el papel relativo de las citocinas y par\u00e1metros de peroxidaci\u00f3n lip\u00eddica en la patogenia de la hepatopat\u00eda alcoh\u00f3lica as\u00ed como su relaci\u00f3n con el pron\u00f3stico y mortalidad. actualmente podemos considerar a la hepatopat\u00eda alcoh\u00f3lica como una enfermedad inflamatoria en base a estudios previos que demuestran alteraciones del sistema inmune y elevaci\u00f3n de ciertas citocinas en la misma, tanto en la fase aguda como en la cr\u00f3nica. Estudiamos un grupo de 61 pacientes (53 hombres y 8 mujeres) con consumo activo de alcohol y diagn\u00f3stico de hepatitis aguda alcoh\u00f3lica al ingreso en los que se realiz\u00f3, entre otros, determinaci\u00f3n en los d\u00eda 1 y 7 del ingreso, de interleucina-6, interleucina-8, factor de necrosis tumoral alfa (tnf-alfa), interleucina -4, interleucina-10, interfer\u00f3n gamma (inf-gamma), prote\u00edna c reactiva (pcr) y, como marcador de peroxidaci\u00f3n lipidica, malonildialdeh\u00eddo (mda). encontramos que las citocinas proinflamatorias (il-6, il-8 u tnf-alfa) estaban m\u00e1s elevadas en cirroticos y con clara relaci\u00f3n con la funci\u00f3n y gravedad de la afectaci\u00f3n hep\u00e1tica. Tanto las citocinas de patr\u00f3n th1 (inff-gamma) como de patr\u00f3n th2 (il-4) resultaron elevadas en nuestros pacientes con relaci\u00f3n variable con la funci\u00f3n hep\u00e1tica. Los niveles de ik-10 resultaron en el l\u00edmite bajo de la normalidad en la mayor\u00eda de pacientes y no present\u00f3 relaci\u00f3n con ninguno de los par\u00e1metros de funci\u00f3n hep\u00e1tica analizados. La pcr s\u00f3lo se elev\u00f3 en un 25% de pacientes sin relacionarse con la presencia de infecci\u00f3n; \u00fanicamente se relacion\u00f3 con la funci\u00f3n hep\u00e1tica a la semana de estudio. El mda estaba significativamente elevado en los pacientes cirr\u00f3ticos frente al resto de grupos y presentaba adem\u00e1s clara relaci\u00f3n co<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citocinas y da\u00f1o oxidante en la hepatitis alcoholica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citocinas y da\u00f1o oxidante en la hepatitis alcoholica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sanchez Perez Mar\u00eda  Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Gonz\u00e1lez Reimers<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Hern\u00e1ndez nieto <\/li>\n<li>alicia Conde martel (vocal)<\/li>\n<li>Antonio Milena abril (vocal)<\/li>\n<li>remedios Aleman valls (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sanchez Perez Mar\u00eda Jose El consumo cr\u00f3nico de alcohol supone un problema socio-sanitario de primer orden. Esta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[491,9915],"tags":[10384,94418,10383,9971,57087,73957],"class_list":["post-53181","post","type-post","status-publish","format-standard","hentry","category-gastroenterologia","category-la-laguna","tag-alicia-conde-martel","tag-antonio-milena-abril","tag-emilio-gonzalez-reimers","tag-luis-hernandez-nieto","tag-remedios-aleman-valls","tag-sanchez-perez-maria-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=53181"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53181\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=53181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=53181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=53181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}