{"id":53187,"date":"2018-03-09T22:40:53","date_gmt":"2018-03-09T22:40:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-atp-extracelular-inhibe-la-senalizacion-de-la-trombina-en-plaquetas-humanas\/"},"modified":"2018-03-09T22:40:53","modified_gmt":"2018-03-09T22:40:53","slug":"el-atp-extracelular-inhibe-la-senalizacion-de-la-trombina-en-plaquetas-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/lipidos\/el-atp-extracelular-inhibe-la-senalizacion-de-la-trombina-en-plaquetas-humanas\/","title":{"rendered":"El atp extracelular inhibe la se\u00f1alizaci\u00f3n de la trombina en plaquetas humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaione Burzaco Gal\u00e1n <\/strong><\/h2>\n<p>El atp extracelular inhibe la activaci\u00f3n plaquetaria inducida por el adp actuando como un antagonista competitivo de los receptores del adp, el p2y1 y el p2y2. Aunque se han descrito otros efectos para este nucle\u00f3tido en plaquetas humanas, no se ha caracterizado el papel que lleva a cabo el nucle\u00f3tido de pruina en la activaci\u00f3n plaquetaria inducida por la tormbina. Con el objetivo de investigar la interacci\u00f3n del atp extracelular con la superficie plaquetria, se han caracterizado los mecanismos de inhibici\u00f3n que ejerce sobre la se\u00f1alizaci\u00f3n de la trombina en este tipo celular. los resultados demuestran que el atp aumenta los niveles de camp de forma dependiente de la concentraci\u00f3n y del tiempo de incubaci\u00f3n. observamos adem\u00e1s, que en presencia del \u00e1cido nordihidroguaiar\u00e9tico (ndga) o 15(s)-hidroxieicosatetraenoico, inhibidores de la 12-lopoxigenasa, se revierte significativamente la inhibici\u00f3n del nucle\u00f3tido. adem\u00e1s, aunque el atp bloquea el aumento de los niveles del \u00e1cido 12(s)-hidroxieicosatetraenoico, no disminuye la formaci\u00f3n de su precursor, el \u00e1cido 12(s)-hidroperoxieicosatetraenoico estimulado por la trombina. La preincubaci\u00f3n con sq-22536 (inhibidor de la adenilato ciclasa) y ndga revierte casi por completo la inhibici\u00f3n determinada en presencia del nucle\u00f3tido. por lo tanto, se concluye que el atp extracelular ejerce su efecto de inhibici\u00f3n sobre la activaci\u00f3n plaquetaria inducida por la trombina al menos a trav\u00e9s de dos v\u00edas de se\u00f1alizaci\u00f3n diferentes e independientes:     1,- antagonizando con el receptor p2y12, bloqueando de este modo la inhibici\u00f3n de la adenilato ciclasa.     2,- a trav\u00e9s de otro receptor p2 todav\u00eda no caracterizado, acoplado a la ruta de la 12-lipoxigenasa.     los estudios realizados con la aspirina y la indometacina indican que el receptor p2y2 no es el responsable del efecto del atp. adem\u00e1s, experimentos con ppads se\u00f1alan que ni el receptor p2x1 ni el  p2y1 participan de dicha inhibici\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El atp extracelular inhibe la se\u00f1alizaci\u00f3n de la trombina en plaquetas humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El atp extracelular inhibe la se\u00f1alizaci\u00f3n de la trombina en plaquetas humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaione Burzaco Gal\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Aida Marino Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo Muga villate <\/li>\n<li>Javier Le\u00f3n serrano (vocal)<\/li>\n<li>mercedes Renobales scheifler (vocal)<\/li>\n<li>teresa Padro capmany (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaione Burzaco Gal\u00e1n El atp extracelular inhibe la activaci\u00f3n plaquetaria inducida por el adp actuando como un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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