{"id":53189,"date":"2018-03-09T22:40:53","date_gmt":"2018-03-09T22:40:53","guid":{"rendered":""},"modified":"2018-03-09T22:40:53","modified_gmt":"2018-03-09T22:40:53","slug":"functional-genomics-in-fish-towards-understanding-stress-and-immune-responses-from-a-molecular-level-genomica-funcional-en-peces-aproximacion-de-las-respuestas-de-estres-y-inmune-desde-un-punto-de","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/functional-genomics-in-fish-towards-understanding-stress-and-immune-responses-from-a-molecular-level-genomica-funcional-en-peces-aproximacion-de-las-respuestas-de-estres-y-inmune-desde-un-punto-de\/","title":{"rendered":"Functional genomics in fish: towards understanding stress and immune responses from a molecular level. genomica funcional en peces: aproximaci\u00f3n de las respuestas de estr\u00e9s y inmune desde un punto de vista molecular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laia Ribas Cabezas <\/strong><\/h2>\n<p>La tesis doctoral est\u00e1 basada en estudiar la respuesta inmunol\u00f3gica de los peces frente a modelos de estr\u00e9s desde un punto de vista molecular. la aplicaci\u00f3n de tecnolog\u00edas moleculares como el differential display permitieron identificar y clonar por primera vez en doradas (sparus aurata) el gen enolasa. Este enzima glucol\u00edtico se ha planteado en esta tesis doctoral como un buen marcador molecular para el estudio del bienestar de los peces. mediante el empleo de una plataforma de microarrays dise\u00f1ada espec\u00edficamente para salm\u00f3nido, se comprov\u00f3 que los niveles de mrna de enolasa eran reguladas en diferentes tejidos y en diferentes especies de pez.  Adem\u00e1s, se han estudiado diferentes genes inmunol\u00f3gicos candidatos a ser posibles genes para el estudio del sistema inmunol\u00f3gico de los peces. Estos genes se han estudiado a nivel de expresi\u00f3n en tejidos de truchas (oncorhynchus mykiss) mediante pcr y pcr en tiempo real, y el empleo de metodolog\u00eda biomolecular y bioinform\u00e1tica. Entre ellos, destaca el factor de transcripci\u00f3n pu.1, un gen indispensable para el desarrollo de la hematopoiesis. Este gen, se ha clonado y caracterizado por primera vez en salm\u00f3nidos. La expresi\u00f3n de pu.1 se ha estudiado mediante el empleo de hibridaciones in situ en ri\u00f1on anterior y en cerebro de truchas. Adem\u00e1s, el uso de microarray en estos dos tejidos han permitido hacer un estudio exhaustivo y pionero a nivel de transcript\u00f3mica en peces. El an\u00e1lisis del chip de microarray, ha revelado que grupos de genes se activan o se inhiben en consecuencia de un estr\u00e9s inmunol\u00f3gico.  en resum, esta tesis doctoral ha aplicado el desarrollo de nuevas tecnolog\u00edas moleculares pioneras en peces, como el microarray, la clonaci\u00f3n de nuevas secuencias g\u00e9nicas y la bioinform\u00e1tica. Adem\u00e1s, nos ha aproximado al conocimiento de las respuestas inmunol\u00f3gicas y del estr\u00e9s en peces.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Functional genomics in fish: towards understanding stress and immune responses from a molecular level. genomica funcional en peces: aproximaci\u00f3n de las respuestas de estr\u00e9s y inmune desde un punto de vista molecular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Functional genomics in fish: towards understanding stress and immune responses from a molecular level. genomica funcional en peces: aproximaci\u00f3n de las respuestas de estr\u00e9s y inmune desde un punto de vista molecular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laia Ribas Cabezas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Simon Mackenzie<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Planas vilarnau <\/li>\n<li>Fernando Rodr\u00edquez gonz\u00e1lez (vocal)<\/li>\n<li>anna Bigas salvans (vocal)<\/li>\n<li> Bl\u00e1zquez peinado Mar\u00eda mercedes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laia Ribas Cabezas La tesis doctoral est\u00e1 basada en estudiar la respuesta inmunol\u00f3gica de los peces frente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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