{"id":53191,"date":"2018-03-09T22:40:53","date_gmt":"2018-03-09T22:40:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunodominancia-y-procesamiento-de-epa%c2%adtopos-de-la-glicoprotea%c2%adna-f-del-virus-respiratorio-sincitial-humano-reconocidos-por-linfocitos-t-citotoxicos-cd8-murinos\/"},"modified":"2018-03-09T22:40:53","modified_gmt":"2018-03-09T22:40:53","slug":"inmunodominancia-y-procesamiento-de-epa%c2%adtopos-de-la-glicoprotea%c2%adna-f-del-virus-respiratorio-sincitial-humano-reconocidos-por-linfocitos-t-citotoxicos-cd8-murinos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/inmunodominancia-y-procesamiento-de-epa%c2%adtopos-de-la-glicoprotea%c2%adna-f-del-virus-respiratorio-sincitial-humano-reconocidos-por-linfocitos-t-citotoxicos-cd8-murinos\/","title":{"rendered":"Inmunodominancia y procesamiento de ep\u00edtopos de la glicoprote\u00edna f del virus respiratorio sincitial humano reconocidos por linfocitos t citot\u00f3xicos cd8+ murinos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Johnstone Espa\u00f1a <\/strong><\/h2>\n<p>El virus respiratorio sincitial (vrs) humano es una de las mayores causas de infecciones respiratorias en neonatos y ancianos. La glicoprote\u00edna de fusi\u00f3n (f) del vrs es una diana antig\u00e9nica en el desarrollo de vacunas ya que desencadena una respuesta inmune mediada por anticuerpos y por linfocitos t citot\u00f3xicos cd8+ (ctl). En la prote\u00edna f de la cepa a2 del vrs se han descrito dos ep\u00edtopos de ctl murinos restringidos por h-2kd, los ep\u00edtopos f85-93 y f92-106. Con objeto de estudiar la respuesta inmune frente a la prote\u00edna f del vrs mediada por ctl, en el modelo de rat\u00f3n balb\/c, se generaron in vitro l\u00edneas de ctl policlonales espec\u00edficas de la prote\u00edna f mediante procedimientos que las manten\u00edan monoespec\u00edficas o multiespec\u00edficas. En el segundo caso se ha utilizado de forma novedosa la estimulaci\u00f3n con las c\u00e9lulas bch4 persistentemente infectadas con la cepa long del vrs. Las l\u00edneas de ctl se utilizaron en ensayos funcionales de presentaci\u00f3n de ant\u00edgeno mediante citot\u00f3xicidad o tinci\u00f3n intracelular de citoquinas (ics). Adem\u00e1s, para evaluar la respuesta in vivo de linfocitos t cd8+ se llevaron a cabo ensayos de ics con esplenocitos ex-vivo. Las conclusiones m\u00e1s relevantes de los resultados obtenidos son las siguientes:  &#8211; en la prote\u00edna f de la cepa long del vrs, se conserva el ep\u00edtopo f85-93 presentado por kd y descrito en la cepa a2. Sin embargo, no hay ninguna evidencia de la presencia del ep\u00edtopo f92-106 en la cepa long.  &#8211; la secuencia f249-258 de la prote\u00edna f de la cepa long del vrs es un nuevo ep\u00edtopo presentado por kd a ctl como non\u00e1mero (tymltnsel) o dec\u00e1mero (tymltnsell). La infecci\u00f3n in vivo de ratones balb\/c con vrs o con un virus vaccinia recombinante que codifica la prote\u00edna f del vrs (vvf) induce ctl frente a este ep\u00edtopo.  &#8211; en la respuesta inmune in vivo mediada por linfocitos t cd8+ en ratones balb\/c infectados con vvf, se va estableciendo una inmunodominancia de f85-93 sobre f249-258,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunodominancia y procesamiento de ep\u00edtopos de la glicoprote\u00edna f del virus respiratorio sincitial humano reconocidos por linfocitos t citot\u00f3xicos cd8+ murinos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunodominancia y procesamiento de ep\u00edtopos de la glicoprote\u00edna f del virus respiratorio sincitial humano reconocidos por linfocitos t citot\u00f3xicos cd8+ murinos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Johnstone Espa\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Margarita Del Val Latorre<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda no Esteban rodriguez <\/li>\n<li>dolores Jaraquemada p\u00e9rez de guzm\u00e1n (vocal)<\/li>\n<li>Jos\u00e9 Antonio L\u00f3pez de castro (vocal)<\/li>\n<li>Jos\u00e9 Lasarte Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Johnstone Espa\u00f1a El virus respiratorio sincitial (vrs) humano es una de las mayores causas de infecciones 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