{"id":53195,"date":"2018-03-09T22:40:53","date_gmt":"2018-03-09T22:40:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-principales-citoquinas-que-participan-en-la-infeccion-natural-y-experimental-por-mycoplasma-hyopneumoniae\/"},"modified":"2018-03-09T22:40:53","modified_gmt":"2018-03-09T22:40:53","slug":"estudio-de-las-principales-citoquinas-que-participan-en-la-infeccion-natural-y-experimental-por-mycoplasma-hyopneumoniae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-veterinarias\/estudio-de-las-principales-citoquinas-que-participan-en-la-infeccion-natural-y-experimental-por-mycoplasma-hyopneumoniae\/","title":{"rendered":"Estudio de las principales citoquinas que participan en la infecci\u00f3n natural y experimental por mycoplasma hyopneumoniae"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lorenzo Socorro H\u00e9ctor Onelio <\/strong><\/h2>\n<p>Mycoplasma hyopneumoniae (mh), agente etiol\u00f3gico primario de la neumon\u00eda enzo\u00f3tica porcina (nep), se adhiere al epitelio ciliado de las v\u00edas respiratorias, desde donde desarrolla una bronconeumon\u00eda intersticial, con consolidaci\u00f3n del par\u00e9nquima pulmonar de distribuci\u00f3n craneoventral. Los cambios histol\u00f3gicos m\u00e1s importantes se corresponden con una intensa infiltraci\u00f3n mononuclear y el desarrollo de una hiperplasia del tejido linfoide asociado a bronquios y bronquilos (tlab). durante esta respuesta inmuno-inflamatoria se han detectado diversos factores proteicos solubles, denominados citoquinas, que participan en la activaci\u00f3n, regulaci\u00f3n y mantenimiento de esta respuesta mediante se\u00f1alizaci\u00f3n intercelular. El estudio de las citoquinas durante la nep nos permitir\u00e1 profundizar en el conocimiento de la patogen\u00eda de la enfermedad. este trabajo se ha dividido en dos partes: por un lado, estudiamos la fase natural de la nep en 19 pulmones obtenidos en matadero, determinando la expresi\u00f3n de distintas citoquinas (il-1_il-1_il-2, il-4, il-6,il-8, il-10, il-12, tnf-_ e ifn-_). Mediante t\u00e9cnicas inmunohistoquimicas en tres distintas localizaciones pulmonares (tlab, septos alveolares y exudado broncoalveolar), relacionando estos resultados con las lesiones observadas.  por otro lado, estudiamos la fase experimental de la nep, inoculando 10 lechones con la cepa 75-2002 de mh, sacrificando secuencialmente los animales durante 5 semanas post-infecci\u00f3n, y evaluando los signos cl\u00ednicos, la serolog\u00eda, las lesiones macro y microsc\u00f3picos, la microbiolog\u00eda y los resultados inmunohistoqu\u00edmicos para las distintas citoquinas. en la fase natural de la nep, los animales infectados presentaron un incremento de los niveles de il-1_il-1_il-2, il-4, il-6,il-8, il-10, il-12 y tnf-_ en el tlab, mientras que el engrosamiento  e infiltraci\u00f3n mononuclear en los septos alveolares se relacion\u00f3 con aumentos en la il-1_, il-1_,il-2, il-8 e il-10, en tanto que la exudaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las principales citoquinas que participan en la infecci\u00f3n natural y experimental por mycoplasma hyopneumoniae<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las principales citoquinas que participan en la infecci\u00f3n natural y experimental por mycoplasma hyopneumoniae <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lorenzo Socorro H\u00e9ctor Onelio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Rodriguez Guisado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fern\u00e1ndez rodr\u00edguez Antonio  Jes\u00fas <\/li>\n<li>Jos\u00e9 \u00e9rez ar\u00e9valo (vocal)<\/li>\n<li>lucas Dom\u00ednguez rodr\u00edguez (vocal)<\/li>\n<li>Francisco Jos\u00e9 Pallar\u00e9s mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorenzo Socorro H\u00e9ctor Onelio Mycoplasma hyopneumoniae (mh), agente etiol\u00f3gico primario de la neumon\u00eda enzo\u00f3tica porcina (nep), se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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