{"id":53274,"date":"2018-03-09T22:40:57","date_gmt":"2018-03-09T22:40:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-intramoleculares-de-iniciacion-de-la-transmision-de-senales-por-el-tcr\/"},"modified":"2018-03-09T22:40:57","modified_gmt":"2018-03-09T22:40:57","slug":"mecanismos-intramoleculares-de-iniciacion-de-la-transmision-de-senales-por-el-tcr","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/mecanismos-intramoleculares-de-iniciacion-de-la-transmision-de-senales-por-el-tcr\/","title":{"rendered":"Mecanismos intramoleculares de iniciaci\u00f3n de la transmisi\u00f3n de se\u00f1ales por el tcr"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruth Mu\u00f1oz Risue\u00f1o <\/strong><\/h2>\n<p>La activaci\u00f3n del receptor para el ant\u00edgeno de c\u00e9lulas t (tcr) puede producir diferentes respuestas dependiendo de la naturaleza del p\u00e9ptido antig\u00e9nico enmarcado en el complejo principal de histocompatibilidad (mhcp). Este potencial implica la combinaci\u00f3n de la especificidad del ligando por el tcr y de la activaci\u00f3n de las distintas cascadas intracelulares de se\u00f1alizaci\u00f3n. el mecanismo molecular que permite la discriminaci\u00f3n se conoce parcialmente. el anticuerpo monoclonal apa1\/1 reconoce un ep\u00edtopo en el tallo citos\u00f3lico de cd3e que se expone cuando el tcr es activado completamente. La exposici\u00f3n del ep\u00edtopo de apa1\/1 se produce r\u00e1pida e independientemente de la actividad tiros\u00edn-quinasa; de hecho, esta exposici\u00f3n se produce cuando las c\u00e9lulas son estimuladas a 0\u00c2\u00ba c. \u00fanicamente la estimulaci\u00f3n del tcr con el ligando agonista fuerte induce la exposici\u00f3n del ep\u00edtopo de apa1\/1. En la mayor\u00eda de las c\u00e9lulas t en reposo en ganglios linf\u00e1ticos, el ep\u00edtopo de apa1\/1 no est\u00e1 expuesto, pero tras la inyecci\u00f3n del ant\u00edgeno in vivo, el ep\u00edtopo se expone en la mayor\u00eda de las c\u00e9lulas t espec\u00edficas para el ant\u00edgeno. estos resultados demuestran que el tcr sufre un cambio conformacional tras la uni\u00f3n del mhcp in vitro e in vivo, y se estable una correlaci\u00f3n molecular con la activaci\u00f3n productiva del tcr.  una caracter\u00edstica \u00fanica del tcr es su habilidad para explorar los ligandos de mhcp estructuralmente similares y transmitir diferencialmente las se\u00f1ales bioqu\u00edmicas dependiendo de la fortaleza del reconocimiento del ligando. en el desarrollo de timocitos, los ligandos d\u00e9biles inducen la selecci\u00f3n positiva y los ligandos fuertes inducen la selecci\u00f3n negativa. Una minor\u00eda de timocitos de ratones no transg\u00e9nicos exponen el ep\u00edtopo reconocido por apa1\/1. Las c\u00e9lulas apa1\/1 positivas son dp, est\u00e1n en la corteza y las uniones cortico-medulares y est\u00e1n en contacto con las c\u00e9lulas epiteliales y dendr\u00edticas. La<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos intramoleculares de iniciaci\u00f3n de la transmisi\u00f3n de se\u00f1ales por el tcr<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos intramoleculares de iniciaci\u00f3n de la transmisi\u00f3n de se\u00f1ales por el tcr <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruth Mu\u00f1oz Risue\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Balbino Jose Alarcon Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>Jos\u00e9 ramon Regueiro  gonzalez barros (vocal)<\/li>\n<li>angel Ramirez ortiz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruth Mu\u00f1oz Risue\u00f1o La activaci\u00f3n del receptor para el ant\u00edgeno de c\u00e9lulas t (tcr) puede producir diferentes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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