{"id":53299,"date":"2018-03-09T22:40:57","date_gmt":"2018-03-09T22:40:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/susceptibilidad-genetica-y-alteraciones-somaticas-en-el-cancer-colorrectal-hereditario-no-poliposico\/"},"modified":"2018-03-09T22:40:57","modified_gmt":"2018-03-09T22:40:57","slug":"susceptibilidad-genetica-y-alteraciones-somaticas-en-el-cancer-colorrectal-hereditario-no-poliposico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/susceptibilidad-genetica-y-alteraciones-somaticas-en-el-cancer-colorrectal-hereditario-no-poliposico\/","title":{"rendered":"Susceptibilidad gen\u00e9tica y alteraciones som\u00e1ticas en el c\u00e1ncer colorrectal hereditario no polip\u00f3sico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Sanchez De Abajo <\/strong><\/h2>\n<p>El objetivo principal de la tesis ha sido la caracterizaci\u00f3n molecular de las familias hnpcc espa\u00f1olas. Para ello, se ha hecho un estudio de inestabilidad a microsat\u00e9lites y de expresi\u00f3n por inmunohistoqu\u00edmica de las prote\u00ednas hmlh1, hmsh2, hmsh6 y hpms2 en los tumores de los probandos de las familias seleccionadas pro criterios cl\u00ednicos. Con este estudio se han podido establecer dos grupos de familias, las que ten\u00edan alta inestabilidad en las cuales se estudiaron los genes reparadores implicados en la susceptibilidad al c\u00e1ncer y las de baja inestabilidad en las cuales se estudiaron otros genes de bajo riesgo implicados en el c\u00e1ncer colorrectal. De esta forma se ha caracterizado un subgrupo de familias hnpcc sin defectos en el sistema mmr. en las familias con alteraciones en los genes mmr, se ha dise\u00f1ado un algoritmo de estudio que va permitir optimizar el proceso del an\u00e1lisis gen\u00e9tico en familias hnpcc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Susceptibilidad gen\u00e9tica y alteraciones som\u00e1ticas en el c\u00e1ncer colorrectal hereditario no polip\u00f3sico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Susceptibilidad gen\u00e9tica y alteraciones som\u00e1ticas en el c\u00e1ncer colorrectal hereditario no polip\u00f3sico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Sanchez De Abajo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Trinidad Caldes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel roman Benito de las heras <\/li>\n<li>Miguel de la Hoya mantec\u00f3n (vocal)<\/li>\n<li>antoni Castells grangon (vocal)<\/li>\n<li>la Cueva javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Sanchez De Abajo El objetivo principal de la tesis ha sido la caracterizaci\u00f3n molecular de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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