{"id":53347,"date":"2018-03-09T22:41:00","date_gmt":"2018-03-09T22:41:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-apolipoprotea%c2%adna-e-en-la-infeccion-hematogena-y-en-la-transmision-vertical-del-virus-herpes-simplex-tipo-1-en-raton\/"},"modified":"2018-03-09T22:41:00","modified_gmt":"2018-03-09T22:41:00","slug":"implicacion-de-la-apolipoprotea%c2%adna-e-en-la-infeccion-hematogena-y-en-la-transmision-vertical-del-virus-herpes-simplex-tipo-1-en-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/implicacion-de-la-apolipoprotea%c2%adna-e-en-la-infeccion-hematogena-y-en-la-transmision-vertical-del-virus-herpes-simplex-tipo-1-en-raton\/","title":{"rendered":"Implicaci\u00f3n de la apolipoprote\u00edna e en la infecci\u00f3n hemat\u00f3gena y en la transmisi\u00f3n vertical del virus herpes simplex tipo 1 en rat\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Ram\u00edrez Moreno <\/strong><\/h2>\n<p>En la enfermedad de alzheimer espor\u00e1dica (eae) se encuentran implicado tanto factores gen\u00e9ticos como factores ambientales. Entre estos factores est\u00e1n la edad avanzada, el g\u00e9nero femenino, el alelo e4 del gen de la apolipoprote\u00edna e (apoe), los niveles de apoe y un factor ambiental transmisible hasta ahora desconocido que interviene hasta en un 60% de la varianza total de la enfermedad. En los \u00faltimos a\u00f1os se ha propuesto que el virus herpes simplex tipo 1 (hsv-1) podr\u00eda estar implicado en la etiolog\u00eda de la eae. en estudios epidemiologicos se ha descrito que la combinaci\u00f3n de la presencia del hsv-1 en el cerebro y ser portador del alelo e4 del apoe promueve un aumento del riesgo en padecer la enfermedad. En esta tesis doctoral se presentan resultados que demuestran que los factores anteriormente citados que han sido asociados con la eae, tambi\u00e9n intervienen en la infecci\u00f3n por hsv-1 en rat\u00f3n, tanto durante la fase aguda como durante la latencia. adem\u00e1s se ha descrito la transmisi\u00f3n vertical hemat\u00f3gena del hsv-1 en el rat\u00f3n, la cual puede evitarse mediante terapia con admisnistraci\u00f3n oral de aciclovir. Esta transmisi\u00f3n vertical induce la colonizaci\u00f3n por parte del virus del enc\u00e9falo de la descendencia, invadiendo las neuronas del hipocampo desde donde puede reactivarse mediante est\u00edmulos de estr\u00e9s. De forma paralela se ha demostrado que la edad, el g\u00e9nero femenino, la isoforma humana apoe4 y la dosis g\u00e9nica de apoe se encuentran implicados en la colonizaci\u00f3n del enc\u00e9falo de la descendencia atrav\u00e9s de este tipo de infecci\u00f3n, originando una mayor carga viral en este \u00f3rgano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la apolipoprote\u00edna e en la infecci\u00f3n hemat\u00f3gena y en la transmisi\u00f3n vertical del virus herpes simplex tipo 1 en rat\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la apolipoprote\u00edna e en la infecci\u00f3n hemat\u00f3gena y en la transmisi\u00f3n vertical del virus herpes simplex tipo 1 en rat\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Ram\u00edrez Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>JavierSantos Burgos Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Lozano jos\u00e9 <\/li>\n<li>galo Ram\u00edrez (vocal)<\/li>\n<li>ma\u00edia Medina jos\u00e9 (vocal)<\/li>\n<li>enrique Tabar\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Ram\u00edrez Moreno En la enfermedad de alzheimer espor\u00e1dica (eae) se encuentran implicado tanto factores gen\u00e9ticos como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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