{"id":5335,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/utilidad-de-los-aminoacidos-plasmaticos-en-la-monitorizacion-de-la-toxicidad-hepatica-del-metotrexato-en-el-tratamiento-de-artritis-reumatoide\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"utilidad-de-los-aminoacidos-plasmaticos-en-la-monitorizacion-de-la-toxicidad-hepatica-del-metotrexato-en-el-tratamiento-de-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilidad-de-los-aminoacidos-plasmaticos-en-la-monitorizacion-de-la-toxicidad-hepatica-del-metotrexato-en-el-tratamiento-de-artritis-reumatoide\/","title":{"rendered":"Utilidad de los aminoacidos plasmaticos en la monitorizacion de la toxicidad hepatica del metotrexato en el tratamiento de artritis reumatoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Atanes Sandoval Antonio  Domingo <\/strong><\/h2>\n<p>Introduccion: en la actualidad, solo la biopsia hepatica (hb) permite detectar la fibrosis o cirrosis hepatica inducida por el metotrexato (mtx) en la artritis reumatoide (ar). Objetivo: determinar si los aminoacidos (aas) plasmaticos permiten predecir el da\u00f1o hepatico inducido por el mtx en la ar y, por tanto, sustituir a la bh.  material y metodo: estudiamos 60 pacientes diagnosticados de ar que fueron tratados con mtx en forma de \u00abpulsos orales semanales\u00bb y monitorizados durante un a\u00f1o.  resultados: los cambios en los aas plasmaticos (salvo la metionina) no se correlacionan con las alteraciones histologicas hepaticas encontradas en las bh. Ademas, los aas plasmaticos tienen una pobre sensibilidad y un pobre valor predictivo positivo, asi como una buena especificidad y un buen valor predictivo negativo, para el diagnostico de las lesiones hepaticas inducidas por el mtx en la ar.  conclusion: los aas plasmaticos son poco sensibles para detectar las alteraciones histologicas hepaticas inducidas por el mtx en la ar, por lo que no nos permiten sustituir a la bh en la monitorizacion de la toxicidad hepatica del mtx en dicha enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad de los aminoacidos plasmaticos en la monitorizacion de la toxicidad hepatica del metotrexato en el tratamiento de artritis reumatoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad de los aminoacidos plasmaticos en la monitorizacion de la toxicidad hepatica del metotrexato en el tratamiento de artritis reumatoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Atanes Sandoval Antonio  Domingo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Alvarez Prechous<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Andr\u00e9s Beiras Iglesias <\/li>\n<li> Sanchez Burson Juan  Miguel (vocal)<\/li>\n<li> Paz Fernandez Juan  Manuel (vocal)<\/li>\n<li>Francisco Javier De Toro Santos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Atanes Sandoval Antonio Domingo Introduccion: en la actualidad, solo la biopsia hepatica (hb) permite detectar la fibrosis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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