{"id":53361,"date":"2018-03-09T22:41:00","date_gmt":"2018-03-09T22:41:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expressio-de-zap-70-en-limfa%c2%b2cits-b-normals-i-sa%c2%adndromes-proliferatives-b\/"},"modified":"2018-03-09T22:41:00","modified_gmt":"2018-03-09T22:41:00","slug":"expressio-de-zap-70-en-limfa%c2%b2cits-b-normals-i-sa%c2%adndromes-proliferatives-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/expressio-de-zap-70-en-limfa%c2%b2cits-b-normals-i-sa%c2%adndromes-proliferatives-b\/","title":{"rendered":"Expressi\u00f3 de zap-70 en limf\u00f3cits b normals i s\u00edndromes proliferatives b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Crespo Maull <\/strong><\/h2>\n<p>La leucemia linf\u00e1tica cr\u00f3nica (llc), la m\u00e1s frecuente del mundo occidental, es una enfermedad producida por la proliferaci\u00f3n y c\u00famulo de linfocitos b immuno-incompetentes. Aproximadamente un 50% de los casos presentan mutaciones en el gen de las imunoglobulinas (igvh)5, hecho que indica que pueden haber pasado por el centro germinal. Adem\u00e1s, los pacientes que no presentan mutaciones en igvh tienen mayor probabilidad de presentar un peor pron\u00f3stico. Por estos motivos, actualmente se trabaja en conseguir marcadores que indiquen el estado mutacional de las immunoglobulinas y que sean m\u00e1s f\u00e1ciles y r\u00e1pidos de detectar.  recientemente se ha descrito la presencia del mrna del gen zap-70 en c\u00e9lulas de llc sin mutaciones en igvh. Tambi\u00e9n se ha descrito que la prote\u00edna zap-70, implicada en la transducci\u00f3n de se\u00f1ales a trav\u00e9s del receptor de linfocitos t o tcr, resulta imprescindible para el correcto desarrollo de los linfocitos pro\/preb de ratones. Este hallazgo significa la primera descripci\u00f3n de la participaci\u00f3n de la prote\u00edna zap-70 en un linfocito de linaje b.  la hip\u00f3tesis de trabajo de la presente tesis doctoral es que la expresi\u00f3n de la prote\u00edna zap-70 en llc podr\u00eda estar relacionada con el estado mutacional de las immunoglobulinas y, por lo tanto, con el pron\u00f3stico de la enfermedad. por otro lado, la prote\u00edna zap-70 podr\u00eda estar expresada en linfocitos pro\/pre-b normales humanos, as\u00ed como en las leucemias agudas linfobl\u00e1sticas b (lal-b) derivadas de estos.  de entre todas las poblaciones b normales analizadas por diversos m\u00e9todos anal\u00edticos s\u00f3lo se detect\u00f3 expresi\u00f3n zap-70 en aquellos linfocitos con fenotipo pro\/pre-b, mientras que zap-70 no se detect\u00f3 en ninguna subpoblaci\u00f3n de linfocitos b maduros de diferentes procedencias anat\u00f3micas. En linfocitos b neopl\u00e1sicos, contrariamente, encontramos expresi\u00f3n de zap-70 en neoplasias tanto derivadas de linfocitos pro\/pre-b (lal-b) como de linfocitos b maduro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expressi\u00f3 de zap-70 en limf\u00f3cits b normals i s\u00edndromes proliferatives b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expressi\u00f3 de zap-70 en limf\u00f3cits b normals i s\u00edndromes proliferatives b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Crespo Maull <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Bosch Albareda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: oriol Bachis valldeneu <\/li>\n<li>joan xavier Comella carnice (vocal)<\/li>\n<li>pablo Engel rocamora (vocal)<\/li>\n<li>joaquin Arribas l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Crespo Maull La leucemia linf\u00e1tica cr\u00f3nica (llc), la m\u00e1s frecuente del mundo occidental, es una enfermedad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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