{"id":53363,"date":"2018-03-09T22:41:00","date_gmt":"2018-03-09T22:41:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/correlacion-de-polimorfismos-de-nucleotido-simple-en-carcinoma-colorrectal-metastasico\/"},"modified":"2018-03-09T22:41:00","modified_gmt":"2018-03-09T22:41:00","slug":"correlacion-de-polimorfismos-de-nucleotido-simple-en-carcinoma-colorrectal-metastasico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/correlacion-de-polimorfismos-de-nucleotido-simple-en-carcinoma-colorrectal-metastasico\/","title":{"rendered":"Correlaci\u00f3n de polimorfismos de nucle\u00f3tido simple en carcinoma colorrectal metast\u00e1sico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Morales Chamorro <\/strong><\/h2>\n<p>En carcinoma colorrectal metast\u00e1sico la aparici\u00f3n del 5fu, la modulaci\u00f3n bioqu\u00edmica, la infusi\u00f3n continua de 5fu, los esquemas de poliquimioterapia, y actualmente los f\u00e1rmacos dirigidos contra dianas moleculares espec\u00edficas han conseguido modificar la historia natural de esta neoplasia. El objetivo final de la mayor\u00eda de los tratamientos es prolongar la supervivencia con una toxicidad aceptable. sin embargo, cuando nos encontramos ante un paciente con enfermedad metast\u00e1sica la calidad de vida es un objetivo primario. La tendencia actuale s a individualizar el tratamiento, seleccionando los esquemas de mayor actividad y menor toxicidad. actualmente la dosificaci\u00f3n en quimioterapia se basa en el c\u00e1lculo de la superficie corporal o tambi\u00e9n, en alg\u00fan caso, en la valoraci\u00f3n del \u00e1rea bajo la curva. No obstante, la variabilidad interindividual en el metabolismo farmacol\u00f3gico, as\u00ed como el estrecho margen terap\u00e9utico hacen necesario un replanteamiento. Es necesario introducir variables que informen del perfil enzim\u00e1tico asociado a la activaci\u00f3n y al catabolismo de los distintos productos quimioter\u00e1picos. en nuestro estudio intentamos relacionar polimorfismos de los genes de la superfamilia de enzimas detoxificantes de fase i (citocromo p-450: cyp1b1) y de fase ii (sulfotransferasa: sult1a1, udp-glucoronil-transferasa: ugt1a1, glutathione s-transferasa: gsta1, gstm1, gstt1, gstp1) con el tiempo a la progresi\u00f3n como objetivo primario, y con la respuesta tumoral y\/o la toxicidad como objetivos secundarios, en pacientes diagnosticados de carcinoma colorrectal metast\u00e1sico on irinotecan .5fu como primera l\u00ednea de quimioterapia paliativa. De manera que el an\u00e1lisis de estos polimorfismos permita seleccionar a los pacientes por la toxicidad y\/o el tiempo a la progresi\u00f3n y evitar una toxicidad innecesaria en los pacientes con genotipos asociados a baja actividad antitumoral, en los cuales podr\u00eda plantearse una primera l\u00ednea de quimioterapia paliativa con<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Correlaci\u00f3n de polimorfismos de nucle\u00f3tido simple en carcinoma colorrectal metast\u00e1sico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Correlaci\u00f3n de polimorfismos de nucle\u00f3tido simple en carcinoma colorrectal metast\u00e1sico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Morales Chamorro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Aranda Aguilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li>sebastian Rufian pe\u00f1a (vocal)<\/li>\n<li> Garcia Garc\u00eda Antonio  Luis (vocal)<\/li>\n<li> Moreno nogueira Jos\u00e9 Andr\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Morales Chamorro En carcinoma colorrectal metast\u00e1sico la aparici\u00f3n del 5fu, la modulaci\u00f3n bioqu\u00edmica, la infusi\u00f3n continua [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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