{"id":53372,"date":"2018-03-09T22:41:04","date_gmt":"2018-03-09T22:41:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/formulaciones-topicas-antivirales-para-el-tratamiento-de-herpes-cutaneo-utilizacion-de-modernos-promotores-de-absorcion\/"},"modified":"2018-03-09T22:41:04","modified_gmt":"2018-03-09T22:41:04","slug":"formulaciones-topicas-antivirales-para-el-tratamiento-de-herpes-cutaneo-utilizacion-de-modernos-promotores-de-absorcion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/formulaciones-topicas-antivirales-para-el-tratamiento-de-herpes-cutaneo-utilizacion-de-modernos-promotores-de-absorcion\/","title":{"rendered":"Formulaciones t\u00f3picas antivirales para el tratamiento de herpes cut\u00e1neo: utilizaci\u00f3n de modernos promotores de absorci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gema Galayo Hip\u00f3lito <\/strong><\/h2>\n<p>La familia herpesviridae est\u00e1 constituida por un grupo de virus adn con caracter\u00edsticas morfol\u00f3gicas y biol\u00f3gicas comunes. Todos ellos inducen inclusiones intranucleares en c\u00e9lulas infectadas, y tienen la capacidad de permanecer en estado latente y reactivarse peri\u00f3dicamente dado lugar a recidivas de la enfermedad. Pertenecen a esta familia dos tipos de virus principales: el virus herpes simplex (hsv), en sus dos variantes serol\u00f3gicas principales hsv-1 y hsv-2 (que provocan herpes labial, queratitis herp\u00e9tica y herpes genital y el virus varicela zoster (vzv). Se sabe que el \u00fanico hu\u00e9sped y reservorio conocido para el hsv y el vzv es la especie humana y se calcula que las infecciones recurrentes causadas por el virus herpes simple afectan a m\u00e1s de un tercio de la poblaci\u00f3n total.     el aciclovir (acv) es el f\u00e1rmaco de primera elecci\u00f3n en la profilaxis y tratamiento de infecciones provocadas por estos virus. Es un antiviral de acci\u00f3n virost\u00e1tica con baja toxicidad. El tratamiento s\u00f3lo es efectivo durante la fase de replicaci\u00f3n del virus, puesto que act\u00faa inhibiendo la s\u00edntesis celular de adn viral. Sin embargo, la eficacia terap\u00e9utica del acv cuando se administra t\u00f3picamente para el tratamiento de infecciones mucocut\u00e1neas y genitales recurrentes se ve seriamente comprometida debido a al dificultad del principio activo para atravesar el estrato c\u00f3rneo de la piel en cantidad suficiente para alcanzar de forma efectiva el \u00f3rgano diana: la capa basal de la epidermis, c\u00e9lulas donde se produce la replicaci\u00f3n masiva del virus.  esto se debe, entre otras razones, a las caracter\u00edsticas f\u00edsico-qu\u00edmicas del acv. El objetivo primordial del presente estudio experimental y bibliogr\u00e1fico es el de desarrollar una nueva formulaci\u00f3n t\u00f3pica de aciclovir con promotores de absorci\u00f3n que consigan aumentar de una manera efectiva la concentraci\u00f3n del acv en la zona \u00abdiana\u00bb del tratamiento, y que sea por tanto m\u00e1s eficaz en el tratamiento de infecciones<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Formulaciones t\u00f3picas antivirales para el tratamiento de herpes cut\u00e1neo: utilizaci\u00f3n de modernos promotores de absorci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Formulaciones t\u00f3picas antivirales para el tratamiento de herpes cut\u00e1neo: utilizaci\u00f3n de modernos promotores de absorci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gema Galayo Hip\u00f3lito <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel C\u00f3rdoba D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Lozano fern\u00e1ndez <\/li>\n<li>bego\u00f1a Escalera izquierdo (vocal)<\/li>\n<li>Jos\u00e9 Luis Lastres garcia (vocal)<\/li>\n<li>romas Girbes Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gema Galayo Hip\u00f3lito La familia herpesviridae est\u00e1 constituida por un grupo de virus adn con caracter\u00edsticas morfol\u00f3gicas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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