{"id":53426,"date":"2018-03-09T22:41:08","date_gmt":"2018-03-09T22:41:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reacciones-intramoleculares-de-radicales-2-indolilacilo-aplicacion-a-la-sa%c2%adntesis-de-compuestos-indolicos\/"},"modified":"2018-03-09T22:41:08","modified_gmt":"2018-03-09T22:41:08","slug":"reacciones-intramoleculares-de-radicales-2-indolilacilo-aplicacion-a-la-sa%c2%adntesis-de-compuestos-indolicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/reacciones-intramoleculares-de-radicales-2-indolilacilo-aplicacion-a-la-sa%c2%adntesis-de-compuestos-indolicos\/","title":{"rendered":"Reacciones intramoleculares de radicales 2-indolilacilo: aplicaci\u00f3n a la s\u00edntesis de compuestos ind\u00f3licos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francesc Ferrando Ruana <\/strong><\/h2>\n<p>La presente tesis doctoral se sit\u00faa en el contexto de las reacciones intramoleculares de radicales 2-indolilacilo y est\u00e1 constituida, de acuerdo con los objetivos iniciales, por dos partes. La primera parte centra la atenci\u00f3n en la ciclaciones de radicales 2-indolilacilo en condiciones reductoras, empleando alquenos como aceptores radicalarios para la obtenci\u00f3n de estructuras que forman parte de productos naturales y de otros compuestos bioactivos. en este contexto se ha conseguido:     1,- el desarrollo de un nuevo procedimiento de anulaci\u00f3n ind\u00f3lica que permite acceder a cetonas c\u00edclicas 1,2-fusionadas con el indol.     2,- la s\u00edntesis total de alcaloide (+-)-guatambuina y la s\u00edntesis del alcaloide olivacina.     la segunda parte se sit\u00faa en el contexto de las reacciones intramoleculares de radicales 2-indolilacilo sobre sistemas arom\u00e1ticos. los principales logros en esta parte son:     1,- la ciclaci\u00f3n de radicales 2-indolilacilo sobre anillos de benceno en condiciones no reductoras (n-bu6sn2-h) para dar de manera eficiente indolil feil ceeonas tetrac\u00edclicas.     2,- la ciclaci\u00f3n regioselectiva de radicales 2-indolilacilo sobre piridinas en condiciones no reductoras (n-bu6sn2-h) para dar indolil 4-piridil cetonas tetrac\u00edclicas. La efectividad de este protocolo radicalario permite el f\u00e1cil acceso a elipticina quinonas.     3,- la ciclaci\u00f3n de radicales 3-(3-quinolil9metilo-2-indolilacilo en condiciones reductoras (ttmss-aibn) para dar pentaciclos relacionados con la calotrixina, el estado de oxidaci\u00f3n de los cuales varia dependiendo el tipo de sustituyente del nitr\u00f3geno ind\u00f3lico. A partir de un sustrato convenientemente sustituido se ha logrado la s\u00edntesis del alcaloide calotrixina b.     4,- el desarrollo de un protocolo metal free para la ciclaci\u00f3n de radicales 3-(quinolil)metilo-2-indolilacilo, en el cual se hace evidente la importancia del papel del aibn en las reacciones de sustituci\u00f3n homol\u00edtica arom\u00e1tica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reacciones intramoleculares de radicales 2-indolilacilo: aplicaci\u00f3n a la s\u00edntesis de compuestos ind\u00f3licos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reacciones intramoleculares de radicales 2-indolilacilo: aplicaci\u00f3n a la s\u00edntesis de compuestos ind\u00f3licos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francesc Ferrando Ruana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  LLuisa Bennasar Felix<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Bonjoch sese <\/li>\n<li>Jos\u00e9 Manuel Concell\u00f3n gracia (vocal)<\/li>\n<li>odon Arjona loraque (vocal)<\/li>\n<li>pilar Marco Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francesc Ferrando Ruana La presente tesis doctoral se sit\u00faa en el contexto de las reacciones intramoleculares de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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