{"id":53434,"date":"2018-03-09T22:41:08","date_gmt":"2018-03-09T22:41:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-empleados-por-el-receptor-quimiotactico-ccr7-para-regular-la-migracion-de-las-celulas-dendra%c2%adticas\/"},"modified":"2018-03-09T22:41:08","modified_gmt":"2018-03-09T22:41:08","slug":"mecanismos-moleculares-empleados-por-el-receptor-quimiotactico-ccr7-para-regular-la-migracion-de-las-celulas-dendra%c2%adticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-empleados-por-el-receptor-quimiotactico-ccr7-para-regular-la-migracion-de-las-celulas-dendra%c2%adticas\/","title":{"rendered":"Mecanismos moleculares empleados por el receptor quimiot\u00e1ctico ccr7 para regular la migraci\u00f3n de las c\u00e9lulas dendr\u00edticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lorena Riol Blanco <\/strong><\/h2>\n<p>El receptor quimiot\u00e1ctico ccr7 se requiere para guiar las c\u00e9lulas dendr\u00edticas (cds) a los ganglios linf\u00e1ticos donde estas c\u00e9lulas participan en la respuesta inmune primaria. A pesar de la importancia de ccr7, las funciones de este receptor y los mecanismos moleculares que controlan dichas funciones son poco conocidos. adem\u00e1s de la quimiotaxis, ccr7 regula la velocidad migratoria de las cds.  en este trabajo, estudiamos los mecanismos moleculares que regulan la quimiotaxis y la velocidad migratoria dependiente de ccr7 en las cds. ccr7 induce una activaci\u00f3n de los miembros de la familia de las mapks erkl 1\/2, jnk y p38. Dicha activaci\u00f3n depende de la familia de la familia gi de prote\u00ednas g heterotrim\u00e9ricas. Las mapks controlan la quimiotaxis, pero no la velocidad migratoria de las cds. Adem\u00e1s, beta-arrestina regula la activaci\u00f3n de erk1\/2. Ccr7 tambi\u00e9n induce la activaci\u00f3n de pl3k\/akt en las cds, aunque, estas enzimas no regulan ni la quimiotaxis ni la velocidad migratoria en estas c\u00e9lulas. Ccr7 regula la activaci\u00f3n de la peque\u00f1a gtpasa rho, la tirosina quinasa pyk-2 y la prote\u00edna despolimerizadora de f-actina cofilina. sin embargo, estas tres mol\u00e9culas controlan la velocidad de migraci\u00f3n de las cds  pero no la quimiotaxis. La activaci\u00f3n de pyk-2 dependiente de ccr7 se realiza a trav\u00e9s de rho, pero no de gi y src. Pyk-2 y la familia g12\/13 regulan la activaci\u00f3n de cofilina. Por otro lado, demostramos que el d\u00edmero betagamma regula la quiiotaxis y la velocidad migratoria del as cds. Por tanto, hemos identificados dos m\u00f3dulos moleculares independientemente que regulan la quimiotaxis (gi\/mapks) y la velocidad migratoria (rho\/pyk-2\/cofilina) de las cds cuando se estimula el receptor ccr7.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares empleados por el receptor quimiot\u00e1ctico ccr7 para regular la migraci\u00f3n de las c\u00e9lulas dendr\u00edticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares empleados por el receptor quimiot\u00e1ctico ccr7 para regular la migraci\u00f3n de las c\u00e9lulas dendr\u00edticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lorena Riol Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Rodriguez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Regueiro gonz\u00e1lez-ramos Jos\u00e9 ram\u00f3n <\/li>\n<li> Melaldo Garc\u00eda Jos\u00e9 mario (vocal)<\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<li>teresa Iglesias vacas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorena Riol Blanco El receptor quimiot\u00e1ctico ccr7 se requiere para guiar las c\u00e9lulas dendr\u00edticas (cds) a los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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