{"id":53467,"date":"2018-03-09T22:41:08","date_gmt":"2018-03-09T22:41:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-trka-a-traves-del-dominio-intracelular-efecto-de-la-union-a-calmodulina-y-de-la-tirosina-701\/"},"modified":"2018-03-09T22:41:08","modified_gmt":"2018-03-09T22:41:08","slug":"regulacion-de-trka-a-traves-del-dominio-intracelular-efecto-de-la-union-a-calmodulina-y-de-la-tirosina-701","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-trka-a-traves-del-dominio-intracelular-efecto-de-la-union-a-calmodulina-y-de-la-tirosina-701\/","title":{"rendered":"Regulaci\u00f3n de trka a trav\u00e9s del dominio intracelular: efecto de la uni\u00f3n a calmodulina y de la tirosina 701"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pablo Llavall Yolanda De <\/strong><\/h2>\n<p>Trka se descubri\u00f3 como un oncog\u00e9n producto de la fusi\u00f3n de su dominio tirosina kinasa (tk) con la tropomiosina. Posteriormente, aument\u00f3 su inter\u00e9s tras descubrirse que la prote\u00edna nativa constitu\u00eda el receptor del factor de crecimiento nervioso (ngf). se conocen bien los acontecimientos que ocurren tras la uni\u00f3n del ligando al receptor y que dan lugar a la activaci\u00f3n de las v\u00edas de se\u00f1alizaci\u00f3n de las mapk y pl 3-k\/akt. Se sabe que, in vivo, la internalizaci\u00f3n del receptor y su transporte retr\u00f3grado tambi\u00e9n juegan un papel importante para el efecto a largo plazo del ngf y que es una caracter\u00edstica distintiva de otros receptores de factores de crecimiento. la activaci\u00f3n del receptor tambi\u00e9n conlleva un aumento transitorio de ca2+ intracelular. Por ello nos planteamos estudiar la relaci\u00f3n entre la activaci\u00f3n de trka y calmodulina (cam), como sensor de los niveles de ca2+ intracelulares. en primer lugar observamos una interacci\u00f3n directa y ca2+ dependiente entre cam y la mitad c-terminal del dominio intracelular de trka. La primera parte del trabajo se centra en caracterizar esta interacci\u00f3n. para ver el efecto de la uni\u00f3n sobre trk, utilizamos inhibidores de cam. \u00e9stos no impiden la fosforilaci\u00f3n de trka inducida por ngf, pero s\u00ed conlleva la proteolisis del receptor dando lugar a un fragmento con actividad tirosina kinasa constitutiva. Dada la ubicuidad de cam y su importancia en procesos vitales para la c\u00e9lula, el segundo objetivo consisti\u00f3 en buscar el sitio de uni\u00f3n a cam de trka, para as\u00ed poder obtener una construcci\u00f3n de trk en que se perdiera la uni\u00f3n a cam. bas\u00e1ndonos en diversas evidencias, nos centramos en la caracterizaci\u00f3n de una regi\u00f3n que conten\u00eda una tyr fosforilable \/y701) y que adem\u00e1s forma parte de un motivo de internalizaci\u00f3n. La \u00faltima parte del trabajo se centra en describir las caracter\u00edsticas de dicha tyr y su funci\u00f3n, que m\u00e1s all\u00e1 de la relaci\u00f3n con cam, puede constituir una fosforilaci\u00f3n inhibit<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de trka a trav\u00e9s del dominio intracelular: efecto de la uni\u00f3n a calmodulina y de la tirosina 701<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de trka a trav\u00e9s del dominio intracelular: efecto de la uni\u00f3n a calmodulina y de la tirosina 701 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pablo Llavall Yolanda De <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Llovera Tom\u00e1s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Franco fernandez <\/li>\n<li>joaquim Egea navarro (vocal)<\/li>\n<li>dionisio Miguel Mart\u00edn zanca (vocal)<\/li>\n<li>francesc Tebar ramon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Llavall Yolanda De Trka se descubri\u00f3 como un oncog\u00e9n producto de la fusi\u00f3n de su dominio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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