{"id":53493,"date":"2018-03-09T22:41:12","date_gmt":"2018-03-09T22:41:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-fak-focal-adhesion-kinase-en-carcinomas-epidermoides-de-cabeza-y-cuello-implicaciones-fisiopatologicas\/"},"modified":"2018-03-09T22:41:12","modified_gmt":"2018-03-09T22:41:12","slug":"expresion-de-fak-focal-adhesion-kinase-en-carcinomas-epidermoides-de-cabeza-y-cuello-implicaciones-fisiopatologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-de-fak-focal-adhesion-kinase-en-carcinomas-epidermoides-de-cabeza-y-cuello-implicaciones-fisiopatologicas\/","title":{"rendered":"Expresion de fak (focal adhesion kinase) en carcinomas epidermoides de cabeza y cuello.  implicaciones fisiopatologicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Canel Losada <\/strong><\/h2>\n<p>A pesar de los avances en prevenci\u00f3n, detecci\u00f3n temprana y tratamiento, el c\u00e1ncer sigue siendo una causa primordial de muerte prematura en todo el mundo. Est\u00e1 generalmente aceptado que la formaci\u00f3n y la preservaci\u00f3n adecuada de las uniones celulares a la matriz extracelular es imprescindible para el mantenimiento de la diferenciaci\u00f3n de las c\u00e9lulas epiteliales y que su desestabilizaci\u00f3n facilita la des-diferenciaci\u00f3n celular y adquisici\u00f3n de capacidad invasiva, con la consiguiente aparici\u00f3n de carcinomas. Las uniones focales son un tipo de uniones entre la c\u00e9lula y la matriz extracelular a trav\u00e9s de receptores de superficie celular denominados integrinas. La quinasa de adhesi\u00f3n focal (\u00abfocal adhesion kinase\u00bb: fak) es un componente esencial de la ruta de se\u00f1alizaci\u00f3n intracelular dependiente de integrinas. el papel de fak en fisiolog\u00eda celular ha sido extensamente estudiado en c\u00e9lulas sanas, no transformadas, donde se ha observado que regula procesos biol\u00f3gicos que son claves en la patog\u00e9nesis del c\u00e1ncer, como la proliferaci\u00f3n celular, supervivencia, migraci\u00f3n e invasi\u00f3n celular. En carcinomas epidermoides de cabeza y cuello (hnscc), existen observaciones previas que indican sobre-expresi\u00f3n de fak en las c\u00e9lulas tumorales.  el objetivo global de este trabajo de tesis ha sido investigar el significado fisiopatol\u00f3gico de la sobre-expresi\u00f3n de fak en hnscc y contribuir, de este modo, a un mejor conocimiento de los mecanismos y las consecuencias derivadas de su actividad. Con este prop\u00f3sito, en primer lugar se investig\u00f3 la expresi\u00f3n de la prote\u00edna fak en muestras de hnscc, procedentes de pacientes tratados quir\u00fargicamente, as\u00ed como en las met\u00e1stasis ganglionares originadas en los mismos y en los tejidos sanos adyacentes al tumor. La sobre-expresi\u00f3n de fak result\u00f3 ser un evento frecuente y temprano en hnscc que se mantiene durante todos los estad\u00edos de la progresi\u00f3n tumoral. Asimismo, se determin\u00f3 el n\u00fa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de fak (focal adhesion kinase) en carcinomas epidermoides de cabeza y cuello.  implicaciones fisiopatologicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de fak (focal adhesion kinase) en carcinomas epidermoides de cabeza y cuello.  implicaciones fisiopatologicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Canel Losada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Chiara Romero Mar\u00eda  Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 L\u00f3pez barneo <\/li>\n<li>Jaime Marco algarra (vocal)<\/li>\n<li> Astudillo gonzalez Mar\u00eda  aurora (vocal)<\/li>\n<li>Antonio  gonzalo Castellano orozco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Canel Losada A pesar de los avances en prevenci\u00f3n, detecci\u00f3n temprana y tratamiento, el c\u00e1ncer sigue [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,155,9,1027,1226,8846,156],"tags":[34226,118062,118061,25303,4666,118060],"class_list":["post-53493","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-clinicas","category-ciencias-medicas","category-oncologia","category-otorrinolaringologia","category-oviedo","category-patologia","tag-antonio-gonzalo-castellano-orozco","tag-astudillo-gonzalez-maria-aurora","tag-chiara-romero-maria-dolores","tag-jaime-marco-algarra","tag-jose-lopez-barneo","tag-marta-canel-losada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=53493"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53493\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=53493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=53493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=53493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}