{"id":53575,"date":"2018-03-09T22:41:16","date_gmt":"2018-03-09T22:41:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deterioro-congnitivo-y-lesiones-de-sustancia-blanca-en-la-esclerosis-multiple\/"},"modified":"2018-03-09T22:41:16","modified_gmt":"2018-03-09T22:41:16","slug":"deterioro-congnitivo-y-lesiones-de-sustancia-blanca-en-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurologia\/deterioro-congnitivo-y-lesiones-de-sustancia-blanca-en-la-esclerosis-multiple\/","title":{"rendered":"Deterioro congnitivo y lesiones de sustancia blanca en la esclerosis multiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Sepucre Bernad <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple (em) es una enfermedad inflamatoria desmielinizante cr\u00f3nica que afecta predominantemente a la sustancia blanca (sb) del sistema nervioso central. Esta enfermedad provoca una discapacidad f\u00edsica y cognitiva en los pacientes como consecuencia de su diseminaci\u00f3n en tiempo y en espacio. El deterioro cognitivo esta presente en un 40-60% de los pacientes. Sin embargo, la topograf\u00eda estereot\u00e1ctica de las lesiones de sb asociada al deterioro cognitivo de la em continua desconocida. En este trabajo de tesis doctoral se ha investigado esta materia utilizando una metodolog\u00eda voxel-a-voxel de resonancia magn\u00e9tica estructural, se han desarrollado nuevos protocolos para el estudio de las lesiones de sb por medio de mapas de probabilidad de lesi\u00f3n y tambi\u00e9n para el estudio de la relaci\u00f3n entre dichas lesiones y la atrofia de sustancia gris por medio de morfometr\u00eda basada en el voxel. Los pacientes de em (46 sujetos) fueron evaluados cl\u00ednica y neuropsicol\u00f3gicamente. Como resultado se obtuvo la topograf\u00eda de lesiones de sb asociada a los diferentes dominios cognitivos estudiados (memoria verbal, memoria visual, memoria de trabajo, atenci\u00f3n, fluidez verbal). Finalmente, se propone a la em como modelo in vivo para el estudio de la interconectividad cerebral humana de procesos cognitivos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Deterioro congnitivo y lesiones de sustancia blanca en la esclerosis multiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Deterioro congnitivo y lesiones de sustancia blanca en la esclerosis multiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Sepucre Bernad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Villoslada Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: herninia Peraita adrados <\/li>\n<li>Mar\u00eda  asuncion Pastor mu\u00f1oz (vocal)<\/li>\n<li>joan xavier Comella carnice (vocal)<\/li>\n<li>joaquin Fuster carulla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Sepucre Bernad La esclerosis m\u00faltiple (em) es una enfermedad inflamatoria desmielinizante cr\u00f3nica que afecta predominantemente a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749,1880],"tags":[118243,41179,118245,118242,118244,87245],"class_list":["post-53575","post","type-post","status-publish","format-standard","hentry","category-navarra","category-neurologia","tag-herninia-peraita-adrados","tag-joan-xavier-comella-carnice","tag-joaquin-fuster-carulla","tag-jorge-sepucre-bernad","tag-maria-asuncion-pastor-munoz","tag-pablo-villoslada-diaz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=53575"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53575\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=53575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=53575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=53575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}