{"id":5367,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/sintesis-y-estudio-de-la-interaccion-frente-a-receptores-de-dopamina-y-de-serotonina-de-aminoalquilociclanonas-y-derivados-como-antipsicoticos-atipicos\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"sintesis-y-estudio-de-la-interaccion-frente-a-receptores-de-dopamina-y-de-serotonina-de-aminoalquilociclanonas-y-derivados-como-antipsicoticos-atipicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sintesis-y-estudio-de-la-interaccion-frente-a-receptores-de-dopamina-y-de-serotonina-de-aminoalquilociclanonas-y-derivados-como-antipsicoticos-atipicos\/","title":{"rendered":"Sintesis y estudio de la interaccion frente a receptores de dopamina y de serotonina de aminoalquilociclanonas y derivados como antipsicoticos atipicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cid Nu\u00f1ez Jos\u00e9 M. <\/strong><\/h2>\n<p>El haloperidol es hoy en dia uno de los farmacos mas eficaces en el tratamiento de la esquizofrenia. Sin embargo presenta dos inconvenientes principales:  induccion de sintomas extra piramidales e ineficacia frente a los sintomas negativos de la enfermedad (apatia, anhedonia). En la presente memoria hemos realizado modificaciones en la estructura del haloperidol con el objeto de obtener derivados desprovistos de efectos secundarios. Hemos comprobado que cuando el farmacoforo butirofenonico presente en el haloperidol se integra en estructuras conformacionalmente restringidas tipo indanona la actividad antipsicotica se mantiene y los efectos extrapiramidales disminuyen, llegando a desaparecer en algunos de los compuestos sintetizados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y estudio de la interaccion frente a receptores de dopamina y de serotonina de aminoalquilociclanonas y derivados como antipsicoticos atipicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y estudio de la interaccion frente a receptores de dopamina y de serotonina de aminoalquilociclanonas y derivados como antipsicoticos atipicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cid Nu\u00f1ez Jos\u00e9 M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Ravi\u00f1a Rubira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alejandro Fernandez Barrero <\/li>\n<li>Marina Gordaliza Escobar (vocal)<\/li>\n<li>Antonio Monge Vega (vocal)<\/li>\n<li> Fontenla Gil Jos\u00e9 Angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cid Nu\u00f1ez Jos\u00e9 M. El haloperidol es hoy en dia uno de los farmacos mas eficaces en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,183,17,416,977],"tags":[1887,7150,21160,2578,2577,21161],"class_list":["post-5367","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-psicotropicos","category-quimica","category-quimica-organica","category-santiago-de-compostela","tag-alejandro-fernandez-barrero","tag-antonio-monge-vega","tag-cid-nunez-jose-m","tag-enrique-ravina-rubira","tag-fontenla-gil-jose-angel","tag-marina-gordaliza-escobar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/5367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=5367"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/5367\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=5367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=5367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=5367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}