{"id":53793,"date":"2006-05-07T00:00:00","date_gmt":"2006-05-07T00:00:00","guid":{"rendered":""},"modified":"2006-05-07T00:00:00","modified_gmt":"2006-05-07T00:00:00","slug":"factores-pronosticos-y-predictivos-de-respuesta-a-quimioterapia-en-el-cancer-colorrectal-estudio-comparativo-de-parametros-clasicos-y-expresion-inmunohistoqua%c2%admica-de-alteraciones-moleculares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-y-predictivos-de-respuesta-a-quimioterapia-en-el-cancer-colorrectal-estudio-comparativo-de-parametros-clasicos-y-expresion-inmunohistoqua%c2%admica-de-alteraciones-moleculares\/","title":{"rendered":"Factores pron\u00f3sticos y predictivos de respuesta a quimioterapia en el c\u00e1ncer colorrectal. estudio comparativo de par\u00e1metros cl\u00e1sicos y expresi\u00f3n inmunohistoqu\u00edmica de alteraciones moleculares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Chao Crecente <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal es la segunda neoplasia m\u00e1s frecuente en los pa\u00edses desarrollados. A pesar de los importantes avances en la cirug\u00eda y la terapia adyuvante, la supervivencia a largo plazo no supera el 50-60%. En el momento del diagn\u00f3stico el 70% de los pacientes se encuentran en estadio b y c. El pron\u00f3stico de los pacientes con adenocarcinoma colorrectal est\u00e1 influido por una serie de factores cl\u00ednicos como edad, sexo, localizaci\u00f3n, obstrucci\u00f3n y perforaci\u00f3n intestinal y de factores histopatol\u00f3gicos, como tipo histol\u00f3gico, diferenciaci\u00f3n, invasi\u00f3n vascular venosa o linf\u00e1tica o invasi\u00f3n perineural. sin embargo, el factor m\u00e1s importante es el estadio tumoral (tnm, dukes, astler-coller), que se basa en el grado de invasi\u00f3n local de la pared intestinal, met\u00e1stasis en ganglios linf\u00e1ticos y la presencia de met\u00e1stasis a distancia. este par\u00e1metro sirve de gu\u00eda en la pr\u00e1ctica cl\u00ednica para seleccionar a los pacientes subsidiarios de tratamiento, pero no es id\u00f3neo para predecir el pron\u00f3stico de pacientes con niveles intermedios de invasi\u00f3n, en los que podr\u00eda haber subgrupos que se beneficiasen de terapia adyuvante. Por ello existe un significativo inter\u00e9s por identificar nuevos par\u00e1metros, que puedan predecir el curso de la enfermedad y determinar el beneficio de una terapia \u00f3ptima.  hip\u00f3tesis     existen par\u00e1metros histol\u00f3gicos e inmunohistoqu\u00edmicos relacionados con la biolog\u00eda tumoral que permiten predecir el pron\u00f3stico y la respuesta al tratamiento en estadios avanzados.  objetivos primarios     1,- identificaci\u00f3n de par\u00e1metros inmunohistoqu\u00edmicos con valor pron\u00f3stico en piezas de resecci\u00f3n colorrectal con carcinoma localmente avanzado (p53, dcc, c-erb-b2, bcl-2 y ki-67).     2,- estudio de la expresi\u00f3n inmunohistoqu\u00edmica de ts como factor predictivo de respuesta al tratamiento.  material y m\u00e9todos     se revisaron retrospectivamente las historias cl\u00ednicas de los pacientes diagnosticados e intervenidos de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3sticos y predictivos de respuesta a quimioterapia en el c\u00e1ncer colorrectal. estudio comparativo de par\u00e1metros cl\u00e1sicos y expresi\u00f3n inmunohistoqu\u00edmica de alteraciones moleculares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3sticos y predictivos de respuesta a quimioterapia en el c\u00e1ncer colorrectal. estudio comparativo de par\u00e1metros cl\u00e1sicos y expresi\u00f3n inmunohistoqu\u00edmica de alteraciones moleculares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Chao Crecente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juli\u00e1n Sanz Esponera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: juliana Fari\u00f1a gonzalez <\/li>\n<li> Puig rullan Ana Mar\u00eda (vocal)<\/li>\n<li>domingo De agustin vazquez (vocal)<\/li>\n<li>felix Manzarbeitia arambarri (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Chao Crecente El c\u00e1ncer colorrectal es la segunda neoplasia m\u00e1s frecuente en los pa\u00edses desarrollados. A [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[118760,102086,6533,6163,118758,118759],"class_list":["post-53793","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-domingo-de-agustin-vazquez","tag-felix-manzarbeitia-arambarri","tag-julian-sanz-esponera","tag-juliana-farina-gonzalez","tag-montserrat-chao-crecente","tag-puig-rullan-ana-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=53793"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/53793\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=53793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=53793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=53793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}