{"id":53852,"date":"2006-07-07T00:00:00","date_gmt":"2006-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adndrome-antifosfolipa%c2%addico-catastrofico\/"},"modified":"2006-07-07T00:00:00","modified_gmt":"2006-07-07T00:00:00","slug":"sa%c2%adndrome-antifosfolipa%c2%addico-catastrofico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/sa%c2%adndrome-antifosfolipa%c2%addico-catastrofico\/","title":{"rendered":"S\u00edndrome antifosfolip\u00eddico catastr\u00f3fico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Bucciarelli <\/strong><\/h2>\n<p>Introducci\u00f3n     el s\u00edndrome antifosfolip\u00eddico catastr\u00f3fico fue descrito por asherson en el a\u00f1o 1992 como una variante del s\u00edndrome antifosfolip\u00eddico (saf) que conduce a insuficiencia multiorg\u00e1nica, caracteriza por la oclusi\u00f3n tromb\u00f3tica de los vasos de peque\u00f1o calibre, que se produce en un breve per\u00edodo de tiempo en presencia de anticuerpos antifosfolip\u00eddico. Representa aproximadamente el 1% de los pacientes con saf, pero la mortalidad es mayor del 50%. Las causas y los factores pron\u00f3sticos que influyen es esta elevada mortalidad son desconocidos.  hip\u00f3tesis     el saf catastr\u00f3fico deber\u00eda ser considerado en el diagn\u00f3stico diferencial de los pacientes con fallo multiorg\u00e1nico (fmo), s\u00edndrome de distr\u00e9s respiratorio agudo (sdra) y anemia hemol\u00edtica microangiop\u00e1tica (ahm). El esquema terap\u00e9utico combinando glucorticoiedes (gc) junto a anticoagulaci\u00f3n efectiva (ac) y recambio plasm\u00e1tico (rp), ser\u00eda el que consigue mayores tasas de supervivencia. Por tanto, la utilizaci\u00f3n de esta triple terapia podr\u00eda mejorar la evoluci\u00f3n de estos pacientes.  objetivos     analizar las caracter\u00edsticas cl\u00ednica y biol\u00f3gica de los pacientes con saf catastr\u00f3fico, especialmente en aquellos que desarrollan sdra y ahm. Determinar las causas y los factores pron\u00f3sticos que condicionan su elevada mortalidad como as\u00ed tambi\u00e9n la influencia del tratamiento en la evoluci\u00f3n de estos enfermos.  material y m\u00e9todos     debido a la baja preValencia del s\u00edndrome es imposible que un solo centro re\u00fana un n\u00famero de pacientes suficientes para realizar estudios de investigaci\u00f3n, por lo que se cre\u00f3 un registro internacional denominado \u00abcaps registry\u00bb con el fin de reunir todos los pacientes con saf catastr\u00f3fico. El servicio de enfermedades autoinmmnes del hospital cl\u00ednico de barcelona es el centro coordinador para la recepci\u00f3n de la informaci\u00f3n y los directores y doctorando de esta tesis son los responsables del dise\u00f1o, confecci\u00f3n y actualizaci\u00f3n d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edndrome antifosfolip\u00eddico catastr\u00f3fico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edndrome antifosfolip\u00eddico catastr\u00f3fico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Bucciarelli <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Font Franco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricard Cervera segura <\/li>\n<li>miquel Vilardell tarres (vocal)<\/li>\n<li> Tassies penella Mar\u00eda  dolors (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Bucciarelli Introducci\u00f3n el s\u00edndrome antifosfolip\u00eddico catastr\u00f3fico fue descrito por asherson en el a\u00f1o 1992 como una 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