{"id":53859,"date":"2006-07-07T00:00:00","date_gmt":"2006-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-disfuncion-de-la-barrera-mucosa-e-inflamacion-en-el-colon-de-ratas-tras-exposicion-a-estres\/"},"modified":"2006-07-07T00:00:00","modified_gmt":"2006-07-07T00:00:00","slug":"mecanismos-de-disfuncion-de-la-barrera-mucosa-e-inflamacion-en-el-colon-de-ratas-tras-exposicion-a-estres","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-disfuncion-de-la-barrera-mucosa-e-inflamacion-en-el-colon-de-ratas-tras-exposicion-a-estres\/","title":{"rendered":"Mecanismos de disfunci\u00f3n de la barrera mucosa e inflamaci\u00f3n en el colon de ratas tras exposici\u00f3n a estr\u00e9s"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Ponferrada Diaz <\/strong><\/h2>\n<p>El estr\u00e9s psicosocial influye en el curso de diversas enfermedades gastrointestinales como el s\u00edndrome de intestino irritable y la enfermedad inflamatoria intestinal aunque los mecanismos no est\u00e1n completamente dilucidados.  material y m\u00e9todos     12 ratas wistar macho fueron sometidas a estr\u00e9s por inmovilizaci\u00f3n en sesiones de 6 horas durante 1(s6h), 5(s5d) y 10 d\u00edas(s10d). En muestras de colon se determinaron: actividad mieloperoxidasas (mpo), expresi\u00f3n y actividad de la inos y cox-2, producci\u00f3n de pge2 (proinflamatoria) y paralelamente la expresi\u00f3n de ppargamma? Y su ligando end\u00f3geno, la pgj2(antiinflamatoria), niveles de iga, estudio de las uniones interceulares epiteliales por microscopia electr\u00f3nica, se tomaron muestras de ganglios mesent\u00e9ricos, bazo e h\u00edgado para cultivo para evaluar la existencia de translocaci\u00f3n bacteriana y la permeabilidad paracelular con niveles plasm\u00e1ticos cr51-edta tras dos horas de su instilaci\u00f3n rectal. Posteriormente se evaluaron los mismos par\u00e1metros tras una inducci\u00f3n de ppargamma con agonistas (pgj2 y rosiglitazona), previa a cada sesi\u00f3n en 6 animales.  resultados     se observ\u00f3 una p\u00e9rdida de peso significativa, un incremento de actividad mpo, translocaci\u00f3n nuclear de nfkb, incremento de expresi\u00f3n y actividad inos, de expresi\u00f3n de cox-2 y de los niveles de pge2. Todos los par\u00e1metros mejoraron progresivamente a lo largo de 5 y 10 d\u00edas paralelamente al incremento de expresi\u00f3n de ppargamma y de la pgj2. Los niveles de iga en mucosa col\u00f3nica fueron significativamente menores en s6h, normaliz\u00e1ndose tras 10 d\u00edas. No hubo translocaci\u00f3n en control ni en s10d, alcanz\u00e1ndose valores m\u00e1ximos en s6h y s5d con predomino de bacilos gram+. La permeabilidad paracelular se increment\u00f3 significativamente en s6h para disminuir progresivamente en s5d y s10d. Paralelamente el estudio de uniones intracelulares revel\u00f3 una apertura m\u00e1xima en s6h, seguida de s5d para cerrarse en s10d. La administraci\u00f3n de pgj2<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de disfunci\u00f3n de la barrera mucosa e inflamaci\u00f3n en el colon de ratas tras exposici\u00f3n a estr\u00e9s<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de disfunci\u00f3n de la barrera mucosa e inflamaci\u00f3n en el colon de ratas tras exposici\u00f3n a estr\u00e9s <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Ponferrada Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Alberto Menchen Viso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Millan nu\u00f1ez cortes <\/li>\n<li>ricardo Moreno otero (vocal)<\/li>\n<li>Francisco Guarner aguilar (vocal)<\/li>\n<li>Jos\u00e9 Miguel Cano l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Ponferrada Diaz El estr\u00e9s psicosocial influye en el curso de diversas enfermedades gastrointestinales como el s\u00edndrome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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