{"id":53871,"date":"2006-07-07T00:00:00","date_gmt":"2006-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-senalizacion-por-glucosa-en-saccharomyces-cerevisiae-a-traves-de-un-mecanismo-nuevo-dependiente-de-hexoquinasa2\/"},"modified":"2006-07-07T00:00:00","modified_gmt":"2006-07-07T00:00:00","slug":"la-senalizacion-por-glucosa-en-saccharomyces-cerevisiae-a-traves-de-un-mecanismo-nuevo-dependiente-de-hexoquinasa2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-senalizacion-por-glucosa-en-saccharomyces-cerevisiae-a-traves-de-un-mecanismo-nuevo-dependiente-de-hexoquinasa2\/","title":{"rendered":"La se\u00f1alizacion por glucosa  en saccharomyces cerevisiae a traves de un mecanismo nuevo dependiente de hexoquinasa2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Deifilia Ahuatzi Chacon <\/strong><\/h2>\n<p>Dos de las prote\u00ednas m\u00e1s importantes implicadas en la represi\u00f3n por glucosa en saccharomyces cerevisiae son mig1 y hxk2. El mecanismo a trav\u00e9s del que opera la prote\u00edna hxk2 no se conoce con precisi\u00f3n pero la parte dependiente de mig1 se conoce con gran detalle. En este trabajo demostramos que la prote\u00edna hxk2 tiene una localizaci\u00f3n nuclear regulada por glucosa y que mig1, un represor transcripcional responsable de la represi\u00f3n por glucosa de muchos genes, se requiere para retener a la prote\u00edna hxk2 en el n\u00facleo. mig1 y hxk2 interaccionan in vivo en un ensayo de doble h\u00edbrido e in vitro en experimentos de inmunoprecipitaci\u00f3n y coprecipitaci\u00f3n tipo \u00abgst-pull down\u00bb. Hemos encontrado que el decap\u00e9ptido k6-m15 de la hxk2, que es necesario para la localizaci\u00f3n nuclear de la prote\u00edna, es tambi\u00e9n esencial para la interacci\u00f3n con mig1. Nuestros resultados demuestran que la interacci\u00f3n hxk2-mig1 es fisiol\u00f3gicamente significativa pues ambas prote\u00ednas se han detectado en un complejo con fragmentos de dna que contienen el sitio mig1 del promotor suc2 tanto in vivo como in vitro. Tambi\u00e9n hemos encontrado que la s311 de mig1 es esencial para la interacci\u00f3n con la prote\u00edna hxk2 y para la localizaci\u00f3n dependiente de snf1 de mig1. Concluimos que hxk2 opera por interacci\u00f3n con mig1, inhibiendo su fosforilaci\u00f3n durante el crecimiento en alta glucosa y generando un complejo represor que se localiza en el promotor de los genes de s. Cerevisiae regulados por mig1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La se\u00f1alizacion por glucosa  en saccharomyces cerevisiae a traves de un mecanismo nuevo dependiente de hexoquinasa2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La se\u00f1alizacion por glucosa  en saccharomyces cerevisiae a traves de un mecanismo nuevo dependiente de hexoquinasa2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Deifilia Ahuatzi Chacon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Moreno Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Gancedo rodr\u00edguez <\/li>\n<li>Jos\u00e9 Manuel Siverio exposito (vocal)<\/li>\n<li>\u00e1ngel Dom\u00ednguez olavarri (vocal)<\/li>\n<li>Carlos Lopez otin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Deifilia Ahuatzi Chacon Dos de las prote\u00ednas m\u00e1s importantes implicadas en la represi\u00f3n por glucosa en saccharomyces [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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