{"id":53874,"date":"2006-07-07T00:00:00","date_gmt":"2006-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfermedad-cardiovascular-asociada-a-la-artritis-reumatoide\/"},"modified":"2006-07-07T00:00:00","modified_gmt":"2006-07-07T00:00:00","slug":"enfermedad-cardiovascular-asociada-a-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/enfermedad-cardiovascular-asociada-a-la-artritis-reumatoide\/","title":{"rendered":"Enfermedad cardiovascular asociada a la artritis reumatoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Gonzalez Juan atey <\/strong><\/h2>\n<p>Hip\u00f3tesis: dado que la arterosclerosis es considerada en la actualidad como un proceso en el que la inflamaci\u00f3n y la trombosis constituyen sus principales mecanismos patogen\u00e9ticos, y donde la producci\u00f3n de citocinas y otras mol\u00e9culas mediadoras de la inflamaci\u00f3n juegan un gran papel clave en la puesta en marcha y desarrollo de la enfermedad aterog\u00e9nica, es posible que en un modelo de enfermedad inflamatoria cr\u00f3nica sist\u00e9mica, como la ar, existan datos bioqu\u00edmicos y cl\u00ednicos de enfermedad vascular ateroscler\u00f3tica. adem\u00e1s, como diferentes alelos de la mol\u00e9cula de hla-drb1 han sido asociados a formas cl\u00ednicas m\u00e1s graves de la enfermedad en pacientes con ar, \u00e9stos podr\u00edan relacionarse con la presencia de enfermedad vascular en la ar.  objetivos: 1. Valorar si pacientes con ar de larga evoluci\u00f3n y sin evidencia cl\u00ednica de enfermedad cardiovascular presentan disfunci\u00f3n endotelial, considerada como un estadio precoz en el desarollo de la enfermedad ateroscler\u00f3tica. 2.Determinar si los pacientes con ar sin ning\u00fan  factor de riesgo cardiovascular cl\u00e1sico ni evidencia cl\u00ednica de enfermedad cardiovascular previa presentan signos de aterosclerosis subcl\u00ednica mediante el an\u00e1lisis del grosor imc y la presencia de placas de ateroma a nivel de la arteria car\u00f3tida. 3.Definir la presencia de enfermedad cardiaca subcl\u00ednica mediante un an\u00e1lisis ecocardiogr\u00e1fico en pacientes con ar de larga evoluci\u00f3n y sin evidencia de eventos cardiovasculares ni factores de riesgo cardiiovascular cl\u00e1sicos. 4. Estudiar la respuesta del endotelio vascular al bloqueo del tnf-a usando un anticuerpo monoclonal de uso habitual en pacientes ar severa y refractaria a terapia inductora de remisi\u00f3n convencional. 5.Valorar si existe progresi\u00f3n de la enfermedad ateroscler\u00f3tica en pacientes ar a pesar del uso peri\u00f3dico de medicaci\u00f3n que bloquea el tnf-a.  m\u00e9todo: estudio de casos y controles en el que se comparan 57 pacientes con ar con controles<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfermedad cardiovascular asociada a la artritis reumatoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfermedad cardiovascular asociada a la artritis reumatoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Gonzalez Juan atey <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Llorca Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Gestal otero <\/li>\n<li> Jose Antonio  amado se\u00c2\u00a5aris (vocal)<\/li>\n<li> Jose ramon berrazueta fernandez (vocal)<\/li>\n<li> Garc\u00ed\u00b6a benavides (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Gonzalez Juan atey Hip\u00f3tesis: dado que la arterosclerosis es considerada en la actualidad como un proceso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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