{"id":53906,"date":"2006-10-07T00:00:00","date_gmt":"2006-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/rutas-de-senalizacion-intracelular-que-regulan-la-apoptosis-inducida-por-lovastatina-en-neuroblastos-fetales-de-rata\/"},"modified":"2006-10-07T00:00:00","modified_gmt":"2006-10-07T00:00:00","slug":"rutas-de-senalizacion-intracelular-que-regulan-la-apoptosis-inducida-por-lovastatina-en-neuroblastos-fetales-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/radicales-libres\/rutas-de-senalizacion-intracelular-que-regulan-la-apoptosis-inducida-por-lovastatina-en-neuroblastos-fetales-de-rata\/","title":{"rendered":"Rutas de se\u00f1alizaci\u00f3n intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Isabel Cerezo Guisado <\/strong><\/h2>\n<p>La p\u00e9rdida gradual de neuronas espec\u00edficas del cerebro mediante el proceso de apoptosis est\u00e1 asociada con la aparici\u00f3n de varias enfermedades neurodegenerativas como el parkinson, la esclerosis lateral amiotr\u00f3fica o el alzheimer y el envejecimiento. Por ello, el proceso de apoptosis neuronal est\u00e1 siendo objeto de numerosos estudios en los \u00faltimos a\u00f1os. estudios recientes realizados en nuestro laboratorio, ponen de manifiesto que la lovastatina, un inhibidor competitivo y reversible de la hmg-coa reductasas, enzima clave de la ruta de bios\u00edntesis de colesterol y de compuestos isoprenoides, es capaz de inhibir el crecimiento e inducir la apoptosis de neuroblastos fetales de rata. Sus efectos est\u00e1n asociados con una disminuci\u00f3n en los niveles de prenilaci\u00f3n de las prote\u00ednas ras y rhoa, lo que sugiere que la apoptosis neuronal inducida por la lovastatina podr\u00eda estar mediada por la activaci\u00f3n o represi\u00f3n de las rutas de transducci\u00f3n de se\u00f1ales reguladas por estas u otras prote\u00ednas preniladas. por tanto, el objetivo general de esta tesis ha sido profundizar en los mecanismos moleculares que controlan la apoptosis neuronal y, en particular, estudiar las rutas de transducci\u00f3n de se\u00f1ales implicadas en la muerte neuronal inducida por lovastatina. El conocimiento de estos mecanismos afectados por la lovastatina puede contribuir a establecer el papel principal que tiene la ruta de bios\u00edntesis del colesterol en el desarrollo del sistema nervioso.     todos los experimentos llevados a cabo en este estudio han sido realizados en una l\u00ednea celular de neuroblastos fetales de rata denominada e18. En particular, se han estudiado las principales rutas de se\u00f1alizaci\u00f3n que regulan la supervivencia celular, las rutas de ras\/erks y pl3\/pkb y las dos principales rutas de se\u00f1alizaci\u00f3n que inducen la muerte celular, las rutas de las jnks y p38 mapks. En este trabajo, hemos mostrado que el tratamiento de los neuroblastos fetales de rata con lovastatina, en las m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Rutas de se\u00f1alizaci\u00f3n intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Rutas de se\u00f1alizaci\u00f3n intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Isabel Cerezo Guisado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jes\u00fas Lorenzo Benayas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fuentes rodriguez Jos\u00e9 manuel <\/li>\n<li>Antonio Chiloeches galvez (vocal)<\/li>\n<li> Cernuda moroll\u00f3n eva Mar\u00eda (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Isabel Cerezo Guisado La p\u00e9rdida gradual de neuronas espec\u00edficas del cerebro mediante el proceso de apoptosis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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