{"id":54030,"date":"2018-03-09T22:41:45","date_gmt":"2018-03-09T22:41:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-rata-antiinflamatoria-15d-pgj2-ppar-gamma-en-cerebro-y-su-modulacion-farmacologica-en-un-modelo-de-estres-en-rata\/"},"modified":"2018-03-09T22:41:45","modified_gmt":"2018-03-09T22:41:45","slug":"estudio-de-la-rata-antiinflamatoria-15d-pgj2-ppar-gamma-en-cerebro-y-su-modulacion-farmacologica-en-un-modelo-de-estres-en-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-rata-antiinflamatoria-15d-pgj2-ppar-gamma-en-cerebro-y-su-modulacion-farmacologica-en-un-modelo-de-estres-en-rata\/","title":{"rendered":"Estudio de la rata antiinflamatoria 15d-pgj2\/ppar gamma en cerebro y su modulaci\u00f3n farmacol\u00f3gica en un modelo de estr\u00e9s en rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Borja Garc\u00eda Bueno <\/strong><\/h2>\n<p>Esta tesis doctoral tiene como objetivos investigar la activaci\u00f3n y regulaci\u00f3n de la ruta antiinflamatoria 15dpgj2\/ppar-gamma en cerebro y su posible modulaci\u00f3n farmacolog\u00eda en un modelo de estr\u00e9s en rata.     los resultados muestran como esta v\u00eda se ve activada por los principales  mediadores del estr\u00e9s (glutamato, catecolaminas y glucocorticoides).     por otro lado, el tratamiento con agonistas ppar gamma produce neuroprotecci\u00f3n en dicho modelo. De esta forma la administraci\u00f3n de los ligandos ppar gamma rosiglitazona y 15d-pgj2 produce una inhibici\u00f3n de las enzimas proinflamatorias cox-2 e inos, fuentes de mediadores oxidativos\/nitrosativos, que se ven activadas por estr\u00e9s agudo en el cerebro de la rata. Estos compuestos tambi\u00e9n bloquean la activaci\u00f3n tras estr\u00e9s de citocinas proinflamatorias como tnf-alfa y de factores nucleares proinflamatorios como nfkb.     por \u00faltimo tras exposici\u00f3n a estr\u00e9s subcr\u00f3nico se produce una ca\u00edda en los niveles de atp provocada por un defectuoso aporte de glucosa a las neuronas, este efecto sit\u00faa a las c\u00e9lulas en un estado de compromiso energ\u00e9tico que aumenta su susceptibilidad a sufrir el proceso de muerte neuronal             por excitotoxicidad glutamat\u00e9rgica. Los resultados recogidos en esta tesis doctoral muestran c\u00f3mo el preparamiento con agonistas ppar gamma previene la reducci\u00f3n de los niveles de atp al facilitar el transporte de glucosa normalizando los niveles del transportador de glucosa neuronal glut-3. Adem\u00e1s estos compuestos reducen la susceptibilidad a excitotoxicidad glutamat\u00e9rgica al regular la expresi\u00f3n del principal recapatador de origen glial de glutamato eaat2.      a partir de estos resultados se puede concluir que el estr\u00e9s activa la ruta antiinflamatoria 15d-pgj2\/ppar gamma y que su modulaci\u00f3n farmacol\u00f3gica ofrece neuroprotecci\u00f3n a distintos niveles, hecho que indica la posible utilidad terap\u00e9utica de los agonistas ppar gamma en neuropat\u00edas asociadas al estr\u00e9s.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la rata antiinflamatoria 15d-pgj2\/ppar gamma en cerebro y su modulaci\u00f3n farmacol\u00f3gica en un modelo de estr\u00e9s en rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la rata antiinflamatoria 15d-pgj2\/ppar gamma en cerebro y su modulaci\u00f3n farmacol\u00f3gica en un modelo de estr\u00e9s en rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Borja Garc\u00eda Bueno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Leza Cerro Juan  Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Navarro Garc\u00eda <\/li>\n<li>c\u00e9sar Venero nu\u00f1ez (vocal)<\/li>\n<li>Jorge Manzanares robles (vocal)<\/li>\n<li> Trejo p\u00e9rez Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Borja Garc\u00eda Bueno Esta tesis doctoral tiene como objetivos investigar la activaci\u00f3n y regulaci\u00f3n de la ruta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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