{"id":54031,"date":"2018-03-09T22:41:45","date_gmt":"2018-03-09T22:41:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-una-va%c2%ada-alternativa-de-presentacion-de-anta%c2%adgenos-por-mhc-de-clase-i-mediada-por-la-tripeptidil-peptidasa-ii\/"},"modified":"2018-03-09T22:41:45","modified_gmt":"2018-03-09T22:41:45","slug":"identificacion-de-una-va%c2%ada-alternativa-de-presentacion-de-anta%c2%adgenos-por-mhc-de-clase-i-mediada-por-la-tripeptidil-peptidasa-ii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/identificacion-de-una-va%c2%ada-alternativa-de-presentacion-de-anta%c2%adgenos-por-mhc-de-clase-i-mediada-por-la-tripeptidil-peptidasa-ii\/","title":{"rendered":"Identificaci\u00f3n de una v\u00edaalternativa de presentaci\u00f3n de ant\u00edgenos por mhc de clase i mediada por la tripeptidil peptidasa ii"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Guil L\u00f3pez <\/strong><\/h2>\n<p>Se estudian las v\u00edas de procesamiento y presentaci\u00f3n de ant\u00edgenos por mhc de clase i de la prote\u00edna de la envuelta del virus de la inmunodeficiencia humana y de la nucleoprote\u00edna del virus de la gripe.     en el caso del procesamiento del ep\u00edtopo r10i (residuos 318-327) de la prote\u00edna de la envuelta presentado por dd, est\u00e1n implicados el proteasoma y una metaloproteasas. El producto del procesamiento de ambas proteasas no requiere recorte.     en el caso del ep\u00edtopo npo147-155 de la nucleoprote\u00edna del virus de la gripe presentado por kd, se estudian las cepas a\/pr\/8\/34 u a\/nt\/60\/68. En el estudio se emplean las n\u00facleo prote\u00ednas nativas de ambas cepas as\u00ed como prote\u00ednas quimera de la prote\u00edna de la c\u00e1psida del virus de la hepatitis b con diferentes insertos de ep\u00edtopo np147-155. Se hab\u00eda postulado que una o varias de las actividades del proteasoma sensibles al inhibidor lactacistina est\u00e1n implicadas en la destrucci\u00f3n del ep\u00edtopo. Se determina ahora que el ep\u00edtopo en s\u00ed, tanto en su contexto natural como en otro diferente, porta la informaci\u00f3n para ser destruido en c\u00e9lulas infectadas.     hay tres factores que influyen en la eficiencia de generaci\u00f3n del ep\u00edtopo np147-155 del virus de la gripe:     1,- secuencia m\u00e1s distal que los 4 aa flaqueantes a cada lado del ep\u00edtopo de la nucleoprote\u00edna de la cepa a\/pr\/8\/34 favorece la eficiencia de procesamiento y generaci\u00f3n del ep\u00edtopo np147-155 respecto de la cepa a\/nt\/60\/68.      2,- la 4 aa que flanquean el ep\u00edtopo no147-155 por cada lado, y en particular en el residuo inmediatamente en amino, causan ligeras diferencias en la eficiencia de generaci\u00f3n del ep\u00edtopo entre ambas cepas.     3,- las secuencias naturales flanqueasteis del ep\u00edtopo np147-155 de ambas cepas favorecen su generaci\u00f3n cuando es presentado en un contexto proteico diferente al suyo natural.     en la generaci\u00f3n del ep\u00edtopo np147-155 del virus de la gripe, tanto a partir del contexto nativo como de otro dif<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de una v\u00edaalternativa de presentaci\u00f3n de ant\u00edgenos por mhc de clase i mediada por la tripeptidil peptidasa ii<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de una v\u00edaalternativa de presentaci\u00f3n de ant\u00edgenos por mhc de clase i mediada por la tripeptidil peptidasa ii <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Guil L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Del Val La Torre Margarita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosalia Rodriguez garcia <\/li>\n<li> Ant\u00f3n canto Luis c. (vocal)<\/li>\n<li>Juan Ortin monton (vocal)<\/li>\n<li> Median prieto Francisco Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Guil L\u00f3pez Se estudian las v\u00edas de procesamiento y presentaci\u00f3n de ant\u00edgenos por mhc de clase [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160],"tags":[119284,119283,14725,119285,23468,119282],"class_list":["post-54031","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","tag-anton-canto-luis-c","tag-del-val-la-torre-margarita","tag-juan-ortin-monton","tag-median-prieto-francisco-manuel","tag-rosalia-rodriguez-garcia","tag-sara-guil-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=54031"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/54031\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=54031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=54031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=54031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}