{"id":54077,"date":"2018-03-09T22:41:45","date_gmt":"2018-03-09T22:41:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-respuesta-hipotalamo-hipofisaria-de-ratas-prepuberes-a-ghrh-y-secretagogos-de-gh-tras-pretratamiento-con-somatostatina\/"},"modified":"2018-03-09T22:41:45","modified_gmt":"2018-03-09T22:41:45","slug":"estudio-de-la-respuesta-hipotalamo-hipofisaria-de-ratas-prepuberes-a-ghrh-y-secretagogos-de-gh-tras-pretratamiento-con-somatostatina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/estudio-de-la-respuesta-hipotalamo-hipofisaria-de-ratas-prepuberes-a-ghrh-y-secretagogos-de-gh-tras-pretratamiento-con-somatostatina\/","title":{"rendered":"Estudio de la respuesta hipot\u00e1lamo-hipofisaria de ratas prep\u00faberes a ghrh y secretagogos de gh tras pretratamiento con somatostatina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Garc\u00eda Martinez <\/strong><\/h2>\n<p>Objetivo     en este trabajo se pretende estudiar, en ratas hembras prep\u00faberes, la respuesta hipofisaria de las c\u00e9lulas somatotropas a hormona liberadora de gh (ghrh) y secretagogos de hormona de crecimiento aislados o en combinaci\u00f3n, para conocer cu\u00e1l es el est\u00edmulo liberador de gh m\u00e1s potente y que cambios suponen sobre la din\u00e1mica de la poblaci\u00f3n somatotropa, comparando su acci\u00f3n con y sin pretratamiento con somatostatina (srih). para el estudio de la reproducibilidad de sus efectos se analiza adem\u00e1s la implicaci\u00f3n hipotal\u00e1mica de los principales n\u00facleos encargados de la regulaci\u00f3n de gh.  material y m\u00e9todos     se utilizaron ratas wistar hembras prep\u00faberes (26-28 d\u00edas) divididas en doce grupos. Seis grupos recibieron como pretratamiento salino y seis recibieron srih al tiempo que denominamos -90 minutos. Al tiempo cero minutos, cada grupo recibi\u00f3 respectivamente salino, ghrh, ghrp-6, ghrelin, ghrh+ghrp-6 y ghrh+ghrelin. El tiempo de estudio concluy\u00f3 a +90 minutos. los animales fueron sacrificados por decapitaci\u00f3n a distintos tiempos para conocer la respuesta a los est\u00edmulos: -90, -15, 0, +15, +30 y +90 minutos. se obtuvieron muestras sangu\u00edneas y los cerebros fueron extra\u00eddos para la obtenci\u00f3n de hipot\u00e1lamos e hip\u00f3fisis. los niveles s\u00e9ricos de gh fueron determinados mediante radioinmunoensayo. Las hip\u00f3fisis, convenientemente fijadas e incluidas en parafina, fueron seccionadas y en los cortes se realiz\u00f3 inmunocitoqu\u00edmica de gh. Se realiz\u00f3 posteriormente recuento de la poblaci\u00f3n somatotropa obteniendo el porcentaje total de c\u00e9lulas osmatotropas y la proporci\u00f3n de c\u00e9lulas densa y d\u00e9bilmente inmunote\u00f1idas. los hipot\u00e1lamos fueron congelados y posteriormente seccionados y las secciones fueron inmunote\u00f1idas con anticuerpos para prote\u00edna c-fos, marcador indirecto de activaci\u00f3n neuronal. Se realiz\u00f3 recuento de las neuronas marcadas con prote\u00edna c-fos en los diferentes n\u00facleos hipotal\u00e1micos implicados: arcuato, peri<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la respuesta hipot\u00e1lamo-hipofisaria de ratas prep\u00faberes a ghrh y secretagogos de gh tras pretratamiento con somatostatina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la respuesta hipot\u00e1lamo-hipofisaria de ratas prep\u00faberes a ghrh y secretagogos de gh tras pretratamiento con somatostatina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Garc\u00eda Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Jimenez Reina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: dolores (secretario) Gonz\u00e1lez lopez <\/li>\n<li>montserrat Anton gamero (vocal)<\/li>\n<li>Manuel Pompo arias (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Garc\u00eda Martinez Objetivo en este trabajo se pretende estudiar, en ratas hembras prep\u00faberes, la respuesta hipofisaria [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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