{"id":54120,"date":"2018-03-09T22:41:49","date_gmt":"2018-03-09T22:41:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-genomico-de-la-regulacion-cruzada-entre-la-resistencia-a-los-antibioticos-y-la-virulencia-en-pseudomonas-aeruginosa\/"},"modified":"2018-03-09T22:41:49","modified_gmt":"2018-03-09T22:41:49","slug":"analisis-genomico-de-la-regulacion-cruzada-entre-la-resistencia-a-los-antibioticos-y-la-virulencia-en-pseudomonas-aeruginosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-genomico-de-la-regulacion-cruzada-entre-la-resistencia-a-los-antibioticos-y-la-virulencia-en-pseudomonas-aeruginosa\/","title":{"rendered":"An\u00e1lisis gen\u00f3mico de la regulaci\u00f3n cruzada entre la resistencia a los antibi\u00f3ticos y la virulencia en pseudomonas aeruginosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Linares Rodr\u00edguez Juan  Francisco <\/strong><\/h2>\n<p>Se ha descrito que la adquisici\u00f3n de un fenotipo de resistencia a antibi\u00f3ticos podr\u00eda estar asociado con una reducci\u00f3n en la virulencia bacteriana. En muchos casos, las razones de esta reducci\u00f3n en la virulencia es desconocida, pero en algunos otros, se comienzan a discernir los mecanismos moleculares subyacentes. Ya que es asumido que adquisici\u00f3n de resistencia a antibi\u00f3ticos produce un defecto general en el metabolismo bacteriano, esto podr\u00eda demostrar la existencia de redes reguladoras que asocien la resistencia a antibi\u00f3ticos y la virulencia bacteriana. El estudio y la comprensi\u00f3n de tales redes tiene una importancia crucial para entender los mecanismos de patogenicidad de las cada vez m\u00e1s numerosas cepas bacterianas resistentes a los antibi\u00f3ticos que producen infecciones. Los elementos que podr\u00edan conectar ambos procesos son los sistemas de bombeo m\u00faltiple de drogas (mdr). Nuestro laboratorio y otros, en modelos como caenorhabditis elegans o dictyostelium discoideum, han demostrado que la sobreproducci\u00f3n de mdr de p. Aeruginosa podr\u00eda reducir virulencia y la adaptabilidad bacteriana. Ya que los mdr pueden expulsar una gran variedad de mol\u00e9culas, la expulsi\u00f3n de mol\u00e9culas de qu\u00f3rum sensing (qs) podr\u00edan ser una de las razones de la reducci\u00f3n de la virulencia en cepas que sobreproducen tales determinantes de resistencia a antibi\u00f3ticos.  en la presente tesis, hemos usado herramientas de gen\u00f3mica funcional, biolog\u00eda molecular, bioqu\u00edmica, microbiolog\u00eda y modelos simples de virulencia para estudiar la regulaci\u00f3n cruzada entre la resistencia a antibi\u00f3ticos y la virulencia en p . Aeruginosa.  se han usado microarrays de oligonucleotidos de p. Aeruginosa pao1 para analizar cambios en el transcriptoma bacteriano asociado a la sobreexpresi\u00f3n de los sistemas mdr mexab-oprm, mexcd-oprj, mexef-oprn y mexxy en p . Aeruginosa. hemos observado que la sobreexpresi\u00f3n de estos sistemas mdr produce cambios en los niveles de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis gen\u00f3mico de la regulaci\u00f3n cruzada entre la resistencia a los antibi\u00f3ticos y la virulencia en pseudomonas aeruginosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis gen\u00f3mico de la regulaci\u00f3n cruzada entre la resistencia a los antibi\u00f3ticos y la virulencia en pseudomonas aeruginosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Linares Rodr\u00edguez Juan  Francisco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Rojo De Castro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Diaz orejas <\/li>\n<li>Juan  alfonso Ayala serrano (vocal)<\/li>\n<li>Jos\u00e9 Berenguer Carlos (vocal)<\/li>\n<li>Jos\u00e9 Antonio Ainsa claver (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Linares Rodr\u00edguez Juan Francisco Se ha descrito que la adquisici\u00f3n de un fenotipo de resistencia a antibi\u00f3ticos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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