{"id":54128,"date":"2018-03-09T22:41:49","date_gmt":"2018-03-09T22:41:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-anatoxina-a-sobre-la-liberacion-de-dopamina-estriatal-un-estudio-in-vivo-mediante-microdialisis-cerebral\/"},"modified":"2018-03-09T22:41:49","modified_gmt":"2018-03-09T22:41:49","slug":"efectos-de-la-anatoxina-a-sobre-la-liberacion-de-dopamina-estriatal-un-estudio-in-vivo-mediante-microdialisis-cerebral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-de-la-anatoxina-a-sobre-la-liberacion-de-dopamina-estriatal-un-estudio-in-vivo-mediante-microdialisis-cerebral\/","title":{"rendered":"Efectos de la anatoxina-a sobre la liberaci\u00f3n de dopamina estriatal. un estudio in vivo mediante microdi\u00e1lisis cerebral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Campos P\u00e9rez <\/strong><\/h2>\n<p>La antoxina-a es una cianotoxina que act\u00faa activando los receptores de ach de tipo nicot\u00ednico. Aunque se conocen algunas caracter\u00edsticas de los efectos agudos producidos por la administraci\u00f3n de anatoxina-a, las caracter\u00edsticas de su mecanismo de acci\u00f3n a nivel neuroqu\u00edmico son menos conocidas. La mayor\u00eda de los estudios con anatoxina-a han sido realizados solamente en condiciones experimentales in vitro, no existiendo ning\u00fan estudio en el que se caractericen los efectos neuroqu\u00edmicos de la toxina en un modelo in vivo.     los objetivos del presente trabajo son los siguientes:     1,- determinar los efectos de la administraci\u00f3n intraestriatal de la anatoxina-a sobre los niveles extracelulares de dopamina y sus metabolitos dopac y hva, en el n\u00facleo estriado de ratas conscientes y en libre movimiento y caracterizar los receptores nicot\u00ednicos y glutamat\u00e9rgicos implicados en el efecto de la anatoxina-a.     3,- estudiar el mecanismo de liberaci\u00f3n (exocit\u00f3tico y\/o a trav\u00e9s del transportador) mediante el cual la activaci\u00f3n de los receptores nicot\u00ednicos por la anatoxina-a induce la liberaci\u00f3n de dopamina.     4,- estudiar la posible participaci\u00f3n del \u00f3xido n\u00edtrico (no) en el efecto de la anatoxina-a.     5,- comprobar la modulaci\u00f3n de los receptores homom\u00e9ricos alfa7* en la liberaci\u00f3n de glutamato, taurina y gaba inducida por la anatoxina-a en el n\u00facleo estriado, y comprobar la posible relaci\u00f3n entre la liberaci\u00f3n de glutamato end\u00f3geno con la liberaci\u00f3n de dopamina, taurina y gaba.     los resultados obtenidos demuestran que la anatoxina-a puede ser utilizada como un importante agonista en el estudio de los receptores nicot\u00ednicos mediante la t\u00e9cnica de microdi\u00e1lisis cerebral in vivo. Adem\u00e1s representa una nueva evidencia in vivo de la mediaci\u00f3n de los receptores ncot\u00ednicos homom\u00e9ricos alfa7* y de los receptores nicot\u00ednicos heterom\u00e9ricos -\/beta2* sobre regulaci\u00f3n de dopamina en el n\u00facleo estriado. la liberaci\u00f3n de dopa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la anatoxina-a sobre la liberaci\u00f3n de dopamina estriatal. un estudio in vivo mediante microdi\u00e1lisis cerebral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la anatoxina-a sobre la liberaci\u00f3n de dopamina estriatal. un estudio in vivo mediante microdi\u00e1lisis cerebral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Campos P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Vigo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Alfonso  Pallares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel alejo Aldegunde villar <\/li>\n<li> Ferreira faro lilian rosana (vocal)<\/li>\n<li>Ana Gago mart\u00ednez (vocal)<\/li>\n<li> Pinto dos santos antunes da cunha rodrigo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Campos P\u00e9rez La antoxina-a es una cianotoxina que act\u00faa activando los receptores de ach de tipo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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