{"id":54143,"date":"2018-03-09T22:41:49","date_gmt":"2018-03-09T22:41:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-papel-del-sistema-kiss-1-gpr54-en-el-control-neuroendocrino-de-la-reproduccion-implicaciones-en-pubertad-y-disrupcion-endocrina\/"},"modified":"2018-03-09T22:41:49","modified_gmt":"2018-03-09T22:41:49","slug":"analisis-del-papel-del-sistema-kiss-1-gpr54-en-el-control-neuroendocrino-de-la-reproduccion-implicaciones-en-pubertad-y-disrupcion-endocrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/analisis-del-papel-del-sistema-kiss-1-gpr54-en-el-control-neuroendocrino-de-la-reproduccion-implicaciones-en-pubertad-y-disrupcion-endocrina\/","title":{"rendered":"An\u00e1lisis del papel del sistema kiss-1\/gpr54 en el control neuroendocrino de la reproducci\u00f3n: implicaciones en pubertad y disrupci\u00f3n endocrina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Navarro Loro Victor Manuel <\/strong><\/h2>\n<p>El sistema kiss-1\/gpr54, inicialmente conocido por su participaci\u00f3n en procesos antimetast\u00e1ticos en diversos tumores, ha sido recientemente implicado en el control del eje gonadotropo mediante diferentes estudios gen\u00e9ticos, aspecto previamente desconocido.      en este sentido, nuestro trabajo utilizando la rata como modelo de estudio se ha dirigido a la caracterizaci\u00f3n de diversos aspectos del papel fisiol\u00f3gico de este sistema en el control de la reproducci\u00f3n.  para ello se ha usado la kisspeptina-10 (kiss-1112-121) de rat\u00f3n para los experimentos funcionales. en el trabajo se describe la expresi\u00f3n persistente de ambos genes en hipot\u00e1lamo a lo largo del desarrollo postnatal en ambos sexos, siendo m\u00e1xima en la pubertad. Esta expresi\u00f3n es sensible al nivel de esteroides gonadales, participando en el control feedback del eje hipot\u00e1lamo-hipofisario-gonadal (hpg). En cuanto a la funcionalidad del p\u00e9ptido derivado del gen kiss-1 (kisspeptina), nuestros resultados muestran una potente acci\u00f3n liberadora de gonadotropinas (lh y fsh) mediada por una acci\u00f3n central sobre la secreci\u00f3n de gnrh. Hay que destacar la existencia de una acci\u00f3n directa sobre hip\u00f3fisis, aunque la magnitud de esta respuesta no justifica la magnitud de la respuesta estimuladora de gonadotropinas observada in vivo. Este sistema juega un papel determinante en la activaci\u00f3n del eje hpg en la pubertad como demuestra el hecho de una activaci\u00f3n precoz del eje gonadotropo en ratas hembras inmaduras tratadas cr\u00f3nicamente con la kisspeptina-10. Adicionalmente, se ha observado que la exposici\u00f3n neonatal a compuestos esteroideos disminuye persistentemente la expresi\u00f3n del gen kiss-1, lo que sugiere la implicaci\u00f3n del sistema kiss-1 en los procesos de diferenciaci\u00f3n sexual del hipot\u00e1lamo, siendo una posible diana a compuestos con actividad disruptora endocrina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis del papel del sistema kiss-1\/gpr54 en el control neuroendocrino de la reproducci\u00f3n: implicaciones en pubertad y disrupci\u00f3n endocrina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis del papel del sistema kiss-1\/gpr54 en el control neuroendocrino de la reproducci\u00f3n: implicaciones en pubertad y disrupci\u00f3n endocrina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Navarro Loro Victor Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2006<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Tena Sempere<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Sanchez criado Jos\u00e9 eugenio <\/li>\n<li>Carlos Dieguez gonzalez (vocal)<\/li>\n<li>justo pastor Casta\u00f1o fuentes (vocal)<\/li>\n<li>Luis Miguel Garc\u00eda segura (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Navarro Loro Victor Manuel El sistema kiss-1\/gpr54, inicialmente conocido por su participaci\u00f3n en procesos antimetast\u00e1ticos en diversos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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